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- NCIT_C200128 IAO_0000115 "A radioconjugate consisting of an Evans blue (EB) modified fibroblast activation protein inhibitor (FAPi), conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecane tetraacetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity. Upon administration of lutetium Lu 177 LNC1004, the FAPi moiety targets and binds to FAP-expressing cancer-associated fibroblasts (CAFs). Upon binding and internalization, the radioconjugate specifically delivers a cytotoxic dose of beta radiation to FAP-expressing CAFs. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME)." @default.
- NCIT_C200128 NCIT_A7 NCIT_C17799 @default.
- NCIT_C200128 NCIT_NHC0 "C200128" @default.
- NCIT_C200128 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200128 NCIT_P108 "Lutetium Lu 177 LNC1004" @default.
- NCIT_C200128 NCIT_P322 "GDC" @default.
- NCIT_C200128 NCIT_P399 "812593" @default.
- NCIT_C200128 normalizedInformationContent "100" @default.
- NCIT_C200128 referenceCount "1" @default.
- NCIT_C200128 hasExactSynonym "177Lu-LNC1004" @default.
- NCIT_C200128 hasExactSynonym "Lutetium Lu 177 LNC1004" @default.
- NCIT_C200128 hasExactSynonym "Lutetium Lu 177-LNC1004" @default.
- NCIT_C200128 inSubset NCIT_C128784 @default.
- NCIT_C200128 inSubset NCIT_C157711 @default.
- NCIT_C200128 inSubset NCIT_C157712 @default.
- NCIT_C200128 inSubset NCIT_C176424 @default.
- NCIT_C200128 type Class @default.
- NCIT_C200128 isDefinedBy ncit.owl @default.
- NCIT_C200128 label "Lutetium Lu 177 LNC1004" @default.
- NCIT_C200128 subClassOf NCIT_C129819 @default.
- NCIT_C200128 subClassOf NCIT_C1446 @default.
- NCIT_C200128 subClassOf NCIT_C1908 @default.
- NCIT_C200128 subClassOf NCIT_C1909 @default.
- NCIT_C200128 subClassOf NCIT_C200128 @default.
- NCIT_C200128 subClassOf NCIT_C2124 @default.
- NCIT_C200128 subClassOf NCIT_C274 @default.