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- NCIT_C200202 IAO_0000115 "An agent targeting both the tumor-associated antigen (TAA) fibroblast activation protein (FAP) and CD40, with potential immunostimulatory and antineoplastic activities. Upon administration, FAP/CD40-targeting agent SHR-7367 targets and binds to both FAP, localized predominantly on cancer-associated fibroblasts (CAFs) in the tumor stroma, and CD40, a cell surface stimulatory receptor expressed on various immune cells including B-lymphocytes, monocytes and dendritic cells (DCs). The simultaneous binding to FAP and CD40 results in local clustering of FAP-expressing tumor stromal cells and CD40-expressing immune cells. Activation of CD40 induces proliferation and activation of B-lymphocytes, shifts the induction of suppressive macrophages towards immunostimulatory macrophages, activates monocyte-derived DCs (moDCs), and leads to the secretion of inflammatory cytokines, which activates the immune system to induce the proliferation and activation of cytotoxic T-lymphocytes (CTLs) against tumor cells. CD40, a member of the tumor necrosis factor receptor superfamily (TNFRSF), plays a key role in the activation of the immune system. FAP is abundantly expressed by CAFs in many solid tumors." @default.
- NCIT_C200202 NCIT_A7 NCIT_C17281 @default.
- NCIT_C200202 NCIT_A7 NCIT_C17799 @default.
- NCIT_C200202 NCIT_NHC0 "C200202" @default.
- NCIT_C200202 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200202 NCIT_P108 "FAP/CD40-targeting Agent SHR-7367" @default.
- NCIT_C200202 NCIT_P322 "GDC" @default.
- NCIT_C200202 NCIT_P399 "812557" @default.
- NCIT_C200202 normalizedInformationContent "100" @default.
- NCIT_C200202 referenceCount "1" @default.
- NCIT_C200202 hasExactSynonym "FAP/CD40-targeting Agent SHR-7367" @default.
- NCIT_C200202 hasExactSynonym "SHR 7367" @default.
- NCIT_C200202 hasExactSynonym "SHR-7367" @default.
- NCIT_C200202 hasExactSynonym "SHR7367" @default.
- NCIT_C200202 inSubset NCIT_C128784 @default.
- NCIT_C200202 inSubset NCIT_C157711 @default.
- NCIT_C200202 inSubset NCIT_C157712 @default.
- NCIT_C200202 inSubset NCIT_C176424 @default.
- NCIT_C200202 type Class @default.
- NCIT_C200202 isDefinedBy ncit.owl @default.
- NCIT_C200202 label "FAP/CD40-targeting Agent SHR-7367" @default.
- NCIT_C200202 subClassOf NCIT_C129820 @default.
- NCIT_C200202 subClassOf NCIT_C1908 @default.
- NCIT_C200202 subClassOf NCIT_C1909 @default.
- NCIT_C200202 subClassOf NCIT_C191767 @default.
- NCIT_C200202 subClassOf NCIT_C200202 @default.
- NCIT_C200202 subClassOf NCIT_C274 @default.
- NCIT_C200202 subClassOf NCIT_C308 @default.