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- NCIT_C200247 IAO_0000115 "An orally bioavailable small molecule inhibitor of the histone deacetylase 1 (HDAC1)-containing co-repressor of repressor element-1 silencing transcription (CoREST) complex, with potential immunomodulating activity. Upon oral administration, CoREST inhibitor TNG260 binds to CoREST complex and inhibits the catalytic activity of HDAC1, which results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This may reverse immune evasion and resistance to immune checkpoint inhibitors caused by serine-threonine kinase 11 (STK11) mutations. Loss-of-function mutations in STK11 is associated with immune checkpoint inhibitor resistance." @default.
- NCIT_C200247 NCIT_NHC0 "C200247" @default.
- NCIT_C200247 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200247 NCIT_P107 "CoREST Inhibitor TNG260" @default.
- NCIT_C200247 NCIT_P108 "CoREST Inhibitor TNG260" @default.
- NCIT_C200247 NCIT_P322 "CTRP" @default.
- NCIT_C200247 NCIT_P322 "GDC" @default.
- NCIT_C200247 NCIT_P399 "812983" @default.
- NCIT_C200247 normalizedInformationContent "100" @default.
- NCIT_C200247 referenceCount "1" @default.
- NCIT_C200247 hasExactSynonym "CoREST Inhibitor TNG260" @default.
- NCIT_C200247 hasExactSynonym "CoREST-selective Deacetylase Inhibitor TNG260" @default.
- NCIT_C200247 hasExactSynonym "CoreDAC Inhibitor TNG260" @default.
- NCIT_C200247 hasExactSynonym "TNG 260" @default.
- NCIT_C200247 hasExactSynonym "TNG-260" @default.
- NCIT_C200247 hasExactSynonym "TNG260" @default.
- NCIT_C200247 inSubset NCIT_C116977 @default.
- NCIT_C200247 inSubset NCIT_C116978 @default.
- NCIT_C200247 inSubset NCIT_C128784 @default.
- NCIT_C200247 inSubset NCIT_C157711 @default.
- NCIT_C200247 inSubset NCIT_C157712 @default.
- NCIT_C200247 inSubset NCIT_C176424 @default.
- NCIT_C200247 type Class @default.
- NCIT_C200247 isDefinedBy ncit.owl @default.
- NCIT_C200247 label "CoREST Inhibitor TNG260" @default.
- NCIT_C200247 subClassOf NCIT_C129824 @default.
- NCIT_C200247 subClassOf NCIT_C129825 @default.
- NCIT_C200247 subClassOf NCIT_C163758 @default.
- NCIT_C200247 subClassOf NCIT_C1908 @default.
- NCIT_C200247 subClassOf NCIT_C1909 @default.
- NCIT_C200247 subClassOf NCIT_C1946 @default.
- NCIT_C200247 subClassOf NCIT_C200247 @default.
- NCIT_C200247 subClassOf NCIT_C2189 @default.
- NCIT_C200247 subClassOf NCIT_C274 @default.
- NCIT_C200247 subClassOf NCIT_C471 @default.