Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C200252> ?p ?o ?g. }
Showing items 1 to 50 of
50
with 100 items per page.
- NCIT_C200252 IAO_0000115 "A liposomal formulation in which gemcitabine, a broad-spectrum antimetabolite and deoxycytidine analogue, is encapsulated in liposomes, with potential antineoplastic activity. Upon administration of gemcitabine liposome FF-10832, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA, resulting in premature termination of DNA replication and the induction of tumor cell apoptosis. In addition, dFdCDP inhibits ribonucleotide reductase (RNR) and reduces the deoxynucleotide pool available for DNA synthesis. This inhibits tumor cell proliferation." @default.
- NCIT_C200252 NCIT_NHC0 "C200252" @default.
- NCIT_C200252 NCIT_P106 "Organic Chemical" @default.
- NCIT_C200252 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200252 NCIT_P108 "Gemcitabine Liposome FF-10832" @default.
- NCIT_C200252 NCIT_R124 NCIT_C17710 @default.
- NCIT_C200252 NCIT_R124 NCIT_C17828 @default.
- NCIT_C200252 NCIT_R124 NCIT_C28498 @default.
- NCIT_C200252 NCIT_R124 NCIT_C40576 @default.
- NCIT_C200252 NCIT_R124 NCIT_C40577 @default.
- NCIT_C200252 NCIT_R125 NCIT_C17710 @default.
- NCIT_C200252 NCIT_R125 NCIT_C17828 @default.
- NCIT_C200252 NCIT_R125 NCIT_C18125 @default.
- NCIT_C200252 NCIT_R125 NCIT_C20150 @default.
- NCIT_C200252 NCIT_R125 NCIT_C20480 @default.
- NCIT_C200252 NCIT_R125 NCIT_C21080 @default.
- NCIT_C200252 NCIT_R125 NCIT_C28498 @default.
- NCIT_C200252 NCIT_R125 NCIT_C40664 @default.
- NCIT_C200252 NCIT_R125 NCIT_C40715 @default.
- NCIT_C200252 NCIT_R125 NCIT_C41515 @default.
- NCIT_C200252 NCIT_R125 NCIT_C41543 @default.
- NCIT_C200252 NCIT_R125 NCIT_C51037 @default.
- NCIT_C200252 NCIT_R146 NCIT_C17101 @default.
- NCIT_C200252 NCIT_R146 NCIT_C21176 @default.
- NCIT_C200252 NCIT_R146 NCIT_C26548 @default.
- NCIT_C200252 normalizedInformationContent "100" @default.
- NCIT_C200252 referenceCount "1" @default.
- NCIT_C200252 hasExactSynonym "FF 10832" @default.
- NCIT_C200252 hasExactSynonym "FF-10832" @default.
- NCIT_C200252 hasExactSynonym "FF10832" @default.
- NCIT_C200252 hasExactSynonym "Gemcitabine Liposome FF-10832" @default.
- NCIT_C200252 hasExactSynonym "Liposomal Gemcitabine FF-10832" @default.
- NCIT_C200252 inSubset NCIT_C128784 @default.
- NCIT_C200252 inSubset NCIT_C176424 @default.
- NCIT_C200252 type Class @default.
- NCIT_C200252 isDefinedBy ncit.owl @default.
- NCIT_C200252 label "Gemcitabine Liposome FF-10832" @default.
- NCIT_C200252 subClassOf B000e88369c0276b8251b0ada846e3c7f @default.
- NCIT_C200252 subClassOf B0a7e7832da047e1db43042e24c8e99c5 @default.
- NCIT_C200252 subClassOf B2cfbc249fdc29038c0d5d564496ada85 @default.
- NCIT_C200252 subClassOf B391470654a03a9d8b2c956ab816097b7 @default.
- NCIT_C200252 subClassOf B57954d043a31a390afe896383ae8aa76 @default.
- NCIT_C200252 subClassOf B64f48ceff759047c5a48e79667d42a21 @default.
- NCIT_C200252 subClassOf Ba80a5f3d3bbed3ba1c59b55323af4ee4 @default.
- NCIT_C200252 subClassOf Bb1ed80a9ef9ceeb41bed7462da70261f @default.
- NCIT_C200252 subClassOf NCIT_C1908 @default.
- NCIT_C200252 subClassOf NCIT_C1909 @default.
- NCIT_C200252 subClassOf NCIT_C200252 @default.
- NCIT_C200252 subClassOf NCIT_C2150 @default.
- NCIT_C200252 subClassOf NCIT_C471 @default.