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- NCIT_C200265 IAO_0000115 "A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, and armed with the anti-inflammatory cytokine interleukin-10 (IL-10), with potential immunostimulating and antineoplastic activities. Upon administration, IL-10-armed anti-CD19 CAR-T cells Meta10-19 recognize and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. IL-10 may stimulate the differentiation and expansion of tumor specific cytotoxic CD8+ T-cells." @default.
- NCIT_C200265 NCIT_A7 NCIT_C38894 @default.
- NCIT_C200265 NCIT_NHC0 "C200265" @default.
- NCIT_C200265 NCIT_P106 "Cell" @default.
- NCIT_C200265 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200265 NCIT_P108 "IL-10-armed Anti-CD19 CAR-T Cells Meta10-19" @default.
- NCIT_C200265 NCIT_P322 "GDC" @default.
- NCIT_C200265 NCIT_P399 "812780" @default.
- NCIT_C200265 normalizedInformationContent "100" @default.
- NCIT_C200265 referenceCount "1" @default.
- NCIT_C200265 hasExactSynonym "IL-10-armed Anti-CD19 CAR T Cells Meta10-19" @default.
- NCIT_C200265 hasExactSynonym "IL-10-armed Anti-CD19 CAR T-cells Meta10-19" @default.
- NCIT_C200265 hasExactSynonym "IL-10-armed Anti-CD19 CAR-T Cells Meta10-19" @default.
- NCIT_C200265 hasExactSynonym "Metabolically Armed CD19 CAR-T Cells Meta10-19" @default.
- NCIT_C200265 inSubset NCIT_C128784 @default.
- NCIT_C200265 inSubset NCIT_C157711 @default.
- NCIT_C200265 inSubset NCIT_C157712 @default.
- NCIT_C200265 inSubset NCIT_C176424 @default.
- NCIT_C200265 type Class @default.
- NCIT_C200265 isDefinedBy ncit.owl @default.
- NCIT_C200265 label "IL-10-armed Anti-CD19 CAR-T Cells Meta10-19" @default.
- NCIT_C200265 subClassOf NCIT_C129820 @default.
- NCIT_C200265 subClassOf NCIT_C129821 @default.
- NCIT_C200265 subClassOf NCIT_C129826 @default.
- NCIT_C200265 subClassOf NCIT_C137999 @default.
- NCIT_C200265 subClassOf NCIT_C142078 @default.
- NCIT_C200265 subClassOf NCIT_C154231 @default.
- NCIT_C200265 subClassOf NCIT_C176018 @default.
- NCIT_C200265 subClassOf NCIT_C1908 @default.
- NCIT_C200265 subClassOf NCIT_C1909 @default.
- NCIT_C200265 subClassOf NCIT_C1962 @default.
- NCIT_C200265 subClassOf NCIT_C200265 @default.
- NCIT_C200265 subClassOf NCIT_C274 @default.
- NCIT_C200265 subClassOf NCIT_C307 @default.
- NCIT_C200265 subClassOf NCIT_C308 @default.