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- NCIT_C200275 IAO_0000115 "A fusion protein composed of a monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), fused with potency reduced interleukin (IL)-15/IL-15 receptor alpha (IL-15Ra) sushi domain complex, with potential immunostimulatory and antineoplastic activities. Upon administration of the anti-PD-L1/IL-15 fusion protein SIM0237, the anti-PD-L1 antibody moiety specifically targets and binds to PD-L1 expressing cells in the tumor microenvironment (TME). In turn, the IL-15/IL-15Ra complex stimulates the proliferation of natural killer (NK) cells, cytotoxic T-lymphocytes (CTLs) and memory T-cells locally in the TME, which induces an anti-tumor immune response. This may increase tumor cell killing and decrease tumor cell proliferation. PD-L1, a transmembrane protein, is expressed on the surface of antigen presenting cells (APCs) and on many cancer cell types. PD-L1 binding to PD-1, a negative regulator of the immune system on activated T-cells, limits the expansion and survival of CD8-positive T-cells, suppresses the immune system and results in immune evasion. IL-15 regulates CD8+ T and NK cell development, activation and proliferation. IL-15Ra complexed with IL-15 increases the half-life of IL-15. The attenuated IL-15 prevents the overstimulation of CD8+ T and NK cells." @default.
- NCIT_C200275 NCIT_A7 NCIT_C96024 @default.
- NCIT_C200275 NCIT_NHC0 "C200275" @default.
- NCIT_C200275 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200275 NCIT_P108 "Anti-PD-L1/IL-15 Fusion Protein SIM0237" @default.
- NCIT_C200275 NCIT_P322 "GDC" @default.
- NCIT_C200275 NCIT_P399 "812785" @default.
- NCIT_C200275 normalizedInformationContent "100" @default.
- NCIT_C200275 referenceCount "1" @default.
- NCIT_C200275 hasExactSynonym "Anti-PD-L1/IL-15 Fusion Protein SIM0237" @default.
- NCIT_C200275 hasExactSynonym "Anti-PD-L1/IL-15/IL-15Ra Sushi Domain Fusion Protein SIM0237" @default.
- NCIT_C200275 hasExactSynonym "SIM 0237" @default.
- NCIT_C200275 hasExactSynonym "SIM-0237" @default.
- NCIT_C200275 hasExactSynonym "SIM0237" @default.
- NCIT_C200275 inSubset NCIT_C128784 @default.
- NCIT_C200275 inSubset NCIT_C157711 @default.
- NCIT_C200275 inSubset NCIT_C157712 @default.
- NCIT_C200275 inSubset NCIT_C176424 @default.
- NCIT_C200275 type Class @default.
- NCIT_C200275 isDefinedBy ncit.owl @default.
- NCIT_C200275 label "Anti-PD-L1/IL-15 Fusion Protein SIM0237" @default.
- NCIT_C200275 subClassOf NCIT_C129820 @default.
- NCIT_C200275 subClassOf NCIT_C129821 @default.
- NCIT_C200275 subClassOf NCIT_C1908 @default.
- NCIT_C200275 subClassOf NCIT_C1909 @default.
- NCIT_C200275 subClassOf NCIT_C200275 @default.
- NCIT_C200275 subClassOf NCIT_C274 @default.
- NCIT_C200275 subClassOf NCIT_C307 @default.
- NCIT_C200275 subClassOf NCIT_C308 @default.