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- NCIT_C200276 IAO_0000115 "An orally bioavailable small molecule inhibitor of all members of the serine/threonine protein kinase Raf family, including A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon oral administration, pan-RAF inhibitor TR128 binds to and inhibits the activity of Raf, including the BRAF V600E mutation. This prevents the activation of Raf-mediated signal transduction pathways, which may inhibit tumor cell growth. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. They play key roles in tumor cell proliferation and survival." @default.
- NCIT_C200276 NCIT_A7 NCIT_C17484 @default.
- NCIT_C200276 NCIT_NHC0 "C200276" @default.
- NCIT_C200276 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200276 NCIT_P108 "pan-RAF Inhibitor TR128" @default.
- NCIT_C200276 NCIT_P322 "GDC" @default.
- NCIT_C200276 NCIT_P399 "812790" @default.
- NCIT_C200276 normalizedInformationContent "100" @default.
- NCIT_C200276 referenceCount "1" @default.
- NCIT_C200276 hasExactSynonym "TR 128" @default.
- NCIT_C200276 hasExactSynonym "TR-128" @default.
- NCIT_C200276 hasExactSynonym "TR128" @default.
- NCIT_C200276 hasExactSynonym "pan-RAF Inhibitor TR128" @default.
- NCIT_C200276 inSubset NCIT_C128784 @default.
- NCIT_C200276 inSubset NCIT_C157711 @default.
- NCIT_C200276 inSubset NCIT_C157712 @default.
- NCIT_C200276 inSubset NCIT_C176424 @default.
- NCIT_C200276 type Class @default.
- NCIT_C200276 isDefinedBy ncit.owl @default.
- NCIT_C200276 label "pan-RAF Inhibitor TR128" @default.
- NCIT_C200276 subClassOf NCIT_C129824 @default.
- NCIT_C200276 subClassOf NCIT_C129825 @default.
- NCIT_C200276 subClassOf NCIT_C1404 @default.
- NCIT_C200276 subClassOf NCIT_C163758 @default.
- NCIT_C200276 subClassOf NCIT_C1908 @default.
- NCIT_C200276 subClassOf NCIT_C1909 @default.
- NCIT_C200276 subClassOf NCIT_C200276 @default.
- NCIT_C200276 subClassOf NCIT_C2189 @default.
- NCIT_C200276 subClassOf NCIT_C2336 @default.
- NCIT_C200276 subClassOf NCIT_C274 @default.
- NCIT_C200276 subClassOf NCIT_C471 @default.
- NCIT_C200276 subClassOf NCIT_C61074 @default.