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- NCIT_C200314 IAO_0000115 "A fourth-generation, orally bioavailable, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, mutant-selective EGFR inhibitor TAS3351 targets, binds to, and inhibits the activity of various EGFR common mutant forms, such as the exon 19 deletion (ex19del) or the L858R point mutation, with or without the resistance mutations T790M and/or C797S, while sparing wild type EGFR activity. This prevents EGFR-mediated signaling, induces cell death and inhibits tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. Compared to other EGFR inhibitors, TAS3351 inhibits EGFR with T790M and C797S resistance mutations." @default.
- NCIT_C200314 NCIT_A7 NCIT_C147011 @default.
- NCIT_C200314 NCIT_NHC0 "C200314" @default.
- NCIT_C200314 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200314 NCIT_P108 "Mutant-selective EGFR Inhibitor TAS3351" @default.
- NCIT_C200314 NCIT_P322 "GDC" @default.
- NCIT_C200314 NCIT_P399 "812621" @default.
- NCIT_C200314 normalizedInformationContent "100" @default.
- NCIT_C200314 referenceCount "1" @default.
- NCIT_C200314 hasExactSynonym "EGFR Inhibitor TAS3351" @default.
- NCIT_C200314 hasExactSynonym "EGFR Mutant-selective Inhibitor TAS3351" @default.
- NCIT_C200314 hasExactSynonym "Mutant-selective EGFR Inhibitor TAS3351" @default.
- NCIT_C200314 hasExactSynonym "TAS 3351" @default.
- NCIT_C200314 hasExactSynonym "TAS-3351" @default.
- NCIT_C200314 hasExactSynonym "TAS3351" @default.
- NCIT_C200314 inSubset NCIT_C128784 @default.
- NCIT_C200314 inSubset NCIT_C157711 @default.
- NCIT_C200314 inSubset NCIT_C157712 @default.
- NCIT_C200314 inSubset NCIT_C176424 @default.
- NCIT_C200314 type Class @default.
- NCIT_C200314 isDefinedBy ncit.owl @default.
- NCIT_C200314 label "Mutant-selective EGFR Inhibitor TAS3351" @default.
- NCIT_C200314 subClassOf NCIT_C129824 @default.
- NCIT_C200314 subClassOf NCIT_C129825 @default.
- NCIT_C200314 subClassOf NCIT_C1404 @default.
- NCIT_C200314 subClassOf NCIT_C163758 @default.
- NCIT_C200314 subClassOf NCIT_C163952 @default.
- NCIT_C200314 subClassOf NCIT_C1908 @default.
- NCIT_C200314 subClassOf NCIT_C1909 @default.
- NCIT_C200314 subClassOf NCIT_C1967 @default.
- NCIT_C200314 subClassOf NCIT_C200314 @default.
- NCIT_C200314 subClassOf NCIT_C2167 @default.
- NCIT_C200314 subClassOf NCIT_C2189 @default.
- NCIT_C200314 subClassOf NCIT_C274 @default.
- NCIT_C200314 subClassOf NCIT_C471 @default.