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- NCIT_C200323 IAO_0000115 "A small molecule protein and selective degrader of the oncoprotein murine double minute 2 (MDM2), with potential immunomodulating and antineoplastic activities. Upon administration, MDM2 degrader KT-253 binds to MDM2 and the E3 (ubiquitin) ligase and targets MDM2 for ubiquitination. This induces proteasome-mediated degradation of MDM2 and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the transcriptional activity of p53 is restored and leads to the stabilization of p53 levels. This leads to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein and a negative regulator of the p53 pathway, is overexpressed in cancer cells; it plays a key role in cancer cell proliferation and survival." @default.
- NCIT_C200323 NCIT_A7 NCIT_C17515 @default.
- NCIT_C200323 NCIT_NHC0 "C200323" @default.
- NCIT_C200323 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200323 NCIT_P107 "MDM2 Degrader KT-253" @default.
- NCIT_C200323 NCIT_P108 "MDM2 Degrader KT-253" @default.
- NCIT_C200323 NCIT_P322 "CTRP" @default.
- NCIT_C200323 NCIT_P322 "GDC" @default.
- NCIT_C200323 NCIT_P399 "812631" @default.
- NCIT_C200323 normalizedInformationContent "100" @default.
- NCIT_C200323 referenceCount "1" @default.
- NCIT_C200323 hasExactSynonym "KT 253" @default.
- NCIT_C200323 hasExactSynonym "KT-253" @default.
- NCIT_C200323 hasExactSynonym "KT253" @default.
- NCIT_C200323 hasExactSynonym "MDM2 Degrader KT-253" @default.
- NCIT_C200323 inSubset NCIT_C116977 @default.
- NCIT_C200323 inSubset NCIT_C116978 @default.
- NCIT_C200323 inSubset NCIT_C128784 @default.
- NCIT_C200323 inSubset NCIT_C157711 @default.
- NCIT_C200323 inSubset NCIT_C157712 @default.
- NCIT_C200323 inSubset NCIT_C176424 @default.
- NCIT_C200323 type Class @default.
- NCIT_C200323 isDefinedBy ncit.owl @default.
- NCIT_C200323 label "MDM2 Degrader KT-253" @default.
- NCIT_C200323 subClassOf NCIT_C129839 @default.
- NCIT_C200323 subClassOf NCIT_C162996 @default.
- NCIT_C200323 subClassOf NCIT_C1908 @default.
- NCIT_C200323 subClassOf NCIT_C1909 @default.
- NCIT_C200323 subClassOf NCIT_C200323 @default.
- NCIT_C200323 subClassOf NCIT_C274 @default.