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- NCIT_C200326 IAO_0000115 "An orally bioavailable inhibitor of nuclear enzyme poly(ADP-ribose) polymerase (PARP) 1, with potential antineoplastic activity. Upon oral administration, PARP1 inhibitor HS-10502 selectively binds to and blocks the activity of PARP1, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. HS-10502 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and plays a key role in the repair of single strand DNA (ssDNA) breaks and double-strand break (DSBs)." @default.
- NCIT_C200326 NCIT_A7 NCIT_C48215 @default.
- NCIT_C200326 NCIT_NHC0 "C200326" @default.
- NCIT_C200326 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200326 NCIT_P108 "PARP1 Inhibitor HS-10502" @default.
- NCIT_C200326 NCIT_P322 "GDC" @default.
- NCIT_C200326 NCIT_P399 "812653" @default.
- NCIT_C200326 NCIT_R146 NCIT_C104101 @default.
- NCIT_C200326 NCIT_R146 NCIT_C16554 @default.
- NCIT_C200326 NCIT_R146 NCIT_C17021 @default.
- NCIT_C200326 NCIT_R146 NCIT_C17210 @default.
- NCIT_C200326 NCIT_R146 NCIT_C17434 @default.
- NCIT_C200326 NCIT_R146 NCIT_C20027 @default.
- NCIT_C200326 NCIT_R146 NCIT_C21170 @default.
- NCIT_C200326 NCIT_R146 NCIT_C26548 @default.
- NCIT_C200326 NCIT_R146 NCIT_C48215 @default.
- NCIT_C200326 normalizedInformationContent "100" @default.
- NCIT_C200326 referenceCount "1" @default.
- NCIT_C200326 hasExactSynonym "HS 10502" @default.
- NCIT_C200326 hasExactSynonym "HS-10502" @default.
- NCIT_C200326 hasExactSynonym "HS10502" @default.
- NCIT_C200326 hasExactSynonym "PARP1 Inhibitor HS-10502" @default.
- NCIT_C200326 inSubset NCIT_C128784 @default.
- NCIT_C200326 inSubset NCIT_C157711 @default.
- NCIT_C200326 inSubset NCIT_C157712 @default.
- NCIT_C200326 inSubset NCIT_C176424 @default.
- NCIT_C200326 type Class @default.
- NCIT_C200326 isDefinedBy ncit.owl @default.
- NCIT_C200326 label "PARP1 Inhibitor HS-10502" @default.
- NCIT_C200326 subClassOf NCIT_C163758 @default.
- NCIT_C200326 subClassOf NCIT_C1908 @default.
- NCIT_C200326 subClassOf NCIT_C1909 @default.
- NCIT_C200326 subClassOf NCIT_C200326 @default.
- NCIT_C200326 subClassOf NCIT_C274 @default.
- NCIT_C200326 subClassOf NCIT_C471 @default.
- NCIT_C200326 subClassOf NCIT_C62554 @default.