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- NCIT_C200344 IAO_0000115 "A preparation of umbilical cord blood (CB)-derived natural killer cells (NKs) that have been engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; tumor-associated calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) and interleukin-15 (IL-15), with potential immunostimulating and antineoplastic activities. Upon administration, anti-TROP2-CAR-IL-15-transduced CB-derived NK cells target, bind to and induce selective cytotoxicity in TROP2-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes persistence of multiple lymphocyte lineages and potentiates the immune response against tumor cells. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival." @default.
- NCIT_C200344 NCIT_A7 NCIT_C18544 @default.
- NCIT_C200344 NCIT_NHC0 "C200344" @default.
- NCIT_C200344 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200344 NCIT_P107 "Anti-TROP2-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells" @default.
- NCIT_C200344 NCIT_P108 "Anti-TROP2-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells" @default.
- NCIT_C200344 NCIT_P322 "CTRP" @default.
- NCIT_C200344 NCIT_P322 "GDC" @default.
- NCIT_C200344 normalizedInformationContent "100" @default.
- NCIT_C200344 referenceCount "1" @default.
- NCIT_C200344 hasExactSynonym "Anti-TROP2-CAR-IL-15-expressing CB-NK Cells" @default.
- NCIT_C200344 hasExactSynonym "Anti-TROP2-CAR-IL-15-transduced CB-derived NK Cells" @default.
- NCIT_C200344 hasExactSynonym "Anti-TROP2-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells" @default.
- NCIT_C200344 hasExactSynonym "Anti-TROP2CAR/IL15-transduced CB-NK Cells" @default.
- NCIT_C200344 hasExactSynonym "TROP2-CAR-IL-15 CBNKs" @default.
- NCIT_C200344 hasExactSynonym "TROP2-CAR-engineered IL15-transduced Cord Blood-derived NKs" @default.
- NCIT_C200344 hasExactSynonym "TROP2-CAR/IL15-transduced CBNK Cells" @default.
- NCIT_C200344 inSubset NCIT_C116977 @default.
- NCIT_C200344 inSubset NCIT_C116978 @default.
- NCIT_C200344 inSubset NCIT_C128784 @default.
- NCIT_C200344 inSubset NCIT_C157711 @default.
- NCIT_C200344 inSubset NCIT_C157712 @default.
- NCIT_C200344 inSubset NCIT_C176424 @default.
- NCIT_C200344 type Class @default.
- NCIT_C200344 isDefinedBy ncit.owl @default.
- NCIT_C200344 label "Anti-TROP2-CAR-IL-15-transduced Cord Blood-derived Natural Killer Cells" @default.
- NCIT_C200344 subClassOf NCIT_C129820 @default.
- NCIT_C200344 subClassOf NCIT_C129821 @default.
- NCIT_C200344 subClassOf NCIT_C129826 @default.
- NCIT_C200344 subClassOf NCIT_C142078 @default.
- NCIT_C200344 subClassOf NCIT_C1908 @default.
- NCIT_C200344 subClassOf NCIT_C1909 @default.
- NCIT_C200344 subClassOf NCIT_C200344 @default.
- NCIT_C200344 subClassOf NCIT_C201545 @default.
- NCIT_C200344 subClassOf NCIT_C274 @default.
- NCIT_C200344 subClassOf NCIT_C307 @default.
- NCIT_C200344 subClassOf NCIT_C308 @default.