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- NCIT_C200345 IAO_0000115 "A liposomal formulation of the semisynthetic camptothecin analogue irinotecan, with potential antineoplastic activity. Upon administration of irinotecan liposome HR070803, irinotecan selectively stabilizes topoisomerase I-DNA covalent complexes during the S phase of the cell cycle, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Liposome encapsulation of this agent promotes efficient drug delivery into the cytosol from the endosome compartment of the cell." @default.
- NCIT_C200345 NCIT_NHC0 "C200345" @default.
- NCIT_C200345 NCIT_P106 "Organic Chemical" @default.
- NCIT_C200345 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200345 NCIT_P108 "Irinotecan Liposome HR070803" @default.
- NCIT_C200345 NCIT_P322 "GDC" @default.
- NCIT_C200345 NCIT_P399 "632436" @default.
- NCIT_C200345 normalizedInformationContent "100" @default.
- NCIT_C200345 referenceCount "1" @default.
- NCIT_C200345 hasExactSynonym "HR 070803" @default.
- NCIT_C200345 hasExactSynonym "HR-070803" @default.
- NCIT_C200345 hasExactSynonym "HR070803" @default.
- NCIT_C200345 hasExactSynonym "Irinotecan Liposome HR070803" @default.
- NCIT_C200345 hasExactSynonym "Liposomal Irinotecan HR070803" @default.
- NCIT_C200345 inSubset NCIT_C128784 @default.
- NCIT_C200345 inSubset NCIT_C157711 @default.
- NCIT_C200345 inSubset NCIT_C157712 @default.
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- NCIT_C200345 type Class @default.
- NCIT_C200345 isDefinedBy ncit.owl @default.
- NCIT_C200345 label "Irinotecan Liposome HR070803" @default.
- NCIT_C200345 subClassOf NCIT_C129824 @default.
- NCIT_C200345 subClassOf NCIT_C129825 @default.
- NCIT_C200345 subClassOf NCIT_C1748 @default.
- NCIT_C200345 subClassOf NCIT_C1904 @default.
- NCIT_C200345 subClassOf NCIT_C1908 @default.
- NCIT_C200345 subClassOf NCIT_C1909 @default.
- NCIT_C200345 subClassOf NCIT_C200345 @default.
- NCIT_C200345 subClassOf NCIT_C2189 @default.
- NCIT_C200345 subClassOf NCIT_C274 @default.
- NCIT_C200345 subClassOf NCIT_C2843 @default.
- NCIT_C200345 subClassOf NCIT_C471 @default.