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- NCIT_C200413 IAO_0000115 "A genetically-engineered, replication competent, optimized E2 transcription factor (E2F)-dependent oncolytic adenovirus (Ad) composed of an Ad serotype 5 (Ad5) backbone that contains genomic modifications to include an Ad5/Ad34 chimeric fiber and dual modifications in E1A and E4orf6/7, and a modified capsid hexon protein, with potential antineoplastic activity. Upon administration, the oncolytic adenovirus ICVB-1042 selectively targets and binds to CD46 that is overexpressed on many cancer cells. Upon viral entry, ICVB-1042 infects and specifically replicates in tumor cells, which may result in tumor cell lysis. ICVB-1042 replicates only in cells with defects in the p16/Rb/E2F pathway, attributed to a mutation common in many solid tumors, and protects normal, non-proliferative cells from viral-mediated toxicity. The Ad5/Ad34 mutation improves viral entry into target tumor cells, enhancing tropism by enabling and increasing viral entry via CD46. The modifications in E1A and E4orf6/7 increases tumor selectivity. The modified capsid hexon protein allows for IV delivery and mediates cell interaction with CD46. ICVB-1042 includes expression of a fluorescent reporter protein (YPet) to aid in tracking viral replication." @default.
- NCIT_C200413 NCIT_NHC0 "C200413" @default.
- NCIT_C200413 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200413 NCIT_P106 "Virus" @default.
- NCIT_C200413 NCIT_P107 "Oncolytic Adenovirus ICVB-1042" @default.
- NCIT_C200413 NCIT_P108 "Oncolytic Adenovirus ICVB-1042" @default.
- NCIT_C200413 NCIT_P322 "CTRP" @default.
- NCIT_C200413 NCIT_P322 "GDC" @default.
- NCIT_C200413 normalizedInformationContent "100" @default.
- NCIT_C200413 referenceCount "1" @default.
- NCIT_C200413 hasExactSynonym "ICVB 042" @default.
- NCIT_C200413 hasExactSynonym "ICVB 1042" @default.
- NCIT_C200413 hasExactSynonym "ICVB-1042" @default.
- NCIT_C200413 hasExactSynonym "Oncolytic Adenovirus ICVB-1042" @default.
- NCIT_C200413 inSubset NCIT_C116977 @default.
- NCIT_C200413 inSubset NCIT_C116978 @default.
- NCIT_C200413 inSubset NCIT_C128784 @default.
- NCIT_C200413 inSubset NCIT_C157711 @default.
- NCIT_C200413 inSubset NCIT_C157712 @default.
- NCIT_C200413 inSubset NCIT_C176424 @default.
- NCIT_C200413 type Class @default.
- NCIT_C200413 isDefinedBy ncit.owl @default.
- NCIT_C200413 label "Oncolytic Adenovirus ICVB-1042" @default.
- NCIT_C200413 subClassOf NCIT_C129821 @default.
- NCIT_C200413 subClassOf NCIT_C1908 @default.
- NCIT_C200413 subClassOf NCIT_C1909 @default.
- NCIT_C200413 subClassOf NCIT_C200413 @default.
- NCIT_C200413 subClassOf NCIT_C274 @default.
- NCIT_C200413 subClassOf NCIT_C307 @default.
- NCIT_C200413 subClassOf NCIT_C717 @default.