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- NCIT_C200451 IAO_0000115 "A fusion protein (~54 kDa) encoded by the NPM1/MLF1 fusion gene. This protein contains 175 N-terminal domain amino acid residues from the nucleophosmin protein, including its dimerization domain and a nuclear localization signal, fused in frame with the myeloid leukemia factor 1 protein (MLF1). Since the nucleophosmin-derived sequences of the NPM1/MLF1 fusion protein can promote its nuclear localization, expression of this fusion protein may result in nuclear localization of MLF1 and lead to aberrant activation of MLF1-dependent transcription factor activity, which may stimulate the differentiation of hemopoietic progenitors into myeloid cells." @default.
- NCIT_C200451 NCIT_A13 NCIT_C21185 @default.
- NCIT_C200451 NCIT_A13 NCIT_C97650 @default.
- NCIT_C200451 NCIT_NHC0 "C200451" @default.
- NCIT_C200451 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C200451 NCIT_P108 "NPM1/MLF1 Fusion Protein" @default.
- NCIT_C200451 NCIT_R54 NCIT_C16612 @default.
- NCIT_C200451 NCIT_R54 NCIT_C200450 @default.
- NCIT_C200451 NCIT_R54 NCIT_C28510 @default.
- NCIT_C200451 normalizedInformationContent "100" @default.
- NCIT_C200451 referenceCount "1" @default.
- NCIT_C200451 hasExactSynonym "NPM-MLF1 Fusion Protein" @default.
- NCIT_C200451 hasExactSynonym "NPM1-MLF1 Fusion Protein" @default.
- NCIT_C200451 hasExactSynonym "NPM1/MLF1 Fusion Protein" @default.
- NCIT_C200451 hasExactSynonym "NPM1::MLF1 Fusion Protein" @default.
- NCIT_C200451 hasExactSynonym "Nucleophosmin/Myeloid Leukemia Factor 1 Fusion Protein" @default.
- NCIT_C200451 type Class @default.
- NCIT_C200451 isDefinedBy ncit.owl @default.
- NCIT_C200451 label "NPM1/MLF1 Fusion Protein" @default.
- NCIT_C200451 subClassOf B7f0e769b134722cf8b44f10c67d0e499 @default.
- NCIT_C200451 subClassOf B9dc0eb75d01063dfe9f4f1f46f443c65 @default.
- NCIT_C200451 subClassOf NCIT_C17021 @default.
- NCIT_C200451 subClassOf NCIT_C17561 @default.
- NCIT_C200451 subClassOf NCIT_C20032 @default.
- NCIT_C200451 subClassOf NCIT_C200451 @default.
- NCIT_C200451 subClassOf NCIT_C26548 @default.