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- NCIT_C200453 IAO_0000115 "The pentahydrate sodium salt form of the naturally occurring mineral and element boron, with potential radioprotective, cryoprotective, antioxidant, apoptotic, wound healing, anti-inflammatory and antineoplastic activities. Upon administration, sodium pentaborate appears to exert various anticancer and protective activities via multiple mechanisms of actions (MoAs) even though the exact MoAs have yet to be fully elucidated. Sodium pentaborate causes gene expression alterations of multiple essential genes, affecting both upregulations and downregulations. Many of the dysregulated genes serve key roles in various biological processes, including the inflammation response, stress response, cellular growth, proliferation, apoptosis and tumorigenesis/oncolysis. Specifically, the upregulation of proapoptotic genes may induce cell cycle arrest at different phases and may decrease tumor cell proliferation in susceptible tumor cells. Sodium pentaborate may also induce oxidative stress which results in the production of reactive oxygen species (ROS) and in enhanced apoptosis, thereby further inducing tumor cell apoptosis." @default.
- NCIT_C200453 NCIT_NHC0 "C200453" @default.
- NCIT_C200453 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200453 NCIT_P108 "Sodium Pentaborate Pentahydrate" @default.
- NCIT_C200453 NCIT_P322 "GDC" @default.
- NCIT_C200453 NCIT_P399 "812852" @default.
- NCIT_C200453 normalizedInformationContent "100" @default.
- NCIT_C200453 referenceCount "1" @default.
- NCIT_C200453 hasExactSynonym "SPP" @default.
- NCIT_C200453 hasExactSynonym "Sodium Pentaborate Pentahydrate" @default.
- NCIT_C200453 hasExactSynonym "Sodium Pentaborate" @default.
- NCIT_C200453 inSubset NCIT_C128784 @default.
- NCIT_C200453 inSubset NCIT_C157711 @default.
- NCIT_C200453 inSubset NCIT_C157712 @default.
- NCIT_C200453 inSubset NCIT_C176424 @default.
- NCIT_C200453 type Class @default.
- NCIT_C200453 isDefinedBy ncit.owl @default.
- NCIT_C200453 label "Sodium Pentaborate Pentahydrate" @default.
- NCIT_C200453 subClassOf NCIT_C129839 @default.
- NCIT_C200453 subClassOf NCIT_C1908 @default.
- NCIT_C200453 subClassOf NCIT_C1909 @default.
- NCIT_C200453 subClassOf NCIT_C200453 @default.
- NCIT_C200453 subClassOf NCIT_C26170 @default.
- NCIT_C200453 subClassOf NCIT_C274 @default.
- NCIT_C200453 subClassOf NCIT_C275 @default.
- NCIT_C200453 subClassOf NCIT_C53306 @default.
- NCIT_C200453 subClassOf NCIT_C797 @default.