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- NCIT_C200456 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against human epidermal growth factor receptor 3 (HER3; ErbB3) conjugated, via a maleimide tetrapeptide-based cleavable linker, to a cytotoxic DNA topoisomerase I inhibitor, with potential antineoplastic activity. Upon administration of anti-HER3 ADC DB-1310, the anti-HER3 antibody moiety targets and binds to HER3 expressed on tumor cells. Upon internalization, the topoisomerase I inhibitor targets and binds to DNA topoisomerase I, thereby stabilizing the cleavable complex between topoisomerase I and DNA and resulting in DNA breaks, inhibition of DNA replication and apoptosis in HER3-expressing tumor cells. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in tumors." @default.
- NCIT_C200456 NCIT_A7 NCIT_C18490 @default.
- NCIT_C200456 NCIT_NHC0 "C200456" @default.
- NCIT_C200456 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200456 NCIT_P107 "Anti-HER3/Topoisomerase I Inhibitor Antibody-drug Conjugate DB-1310" @default.
- NCIT_C200456 NCIT_P108 "Anti-HER3/Topoisomerase I Inhibitor Antibody-drug Conjugate DB-1310" @default.
- NCIT_C200456 NCIT_P322 "CTRP" @default.
- NCIT_C200456 NCIT_P322 "GDC" @default.
- NCIT_C200456 NCIT_P399 "812875" @default.
- NCIT_C200456 normalizedInformationContent "100" @default.
- NCIT_C200456 referenceCount "1" @default.
- NCIT_C200456 hasExactSynonym "Anti-HER3 ADC DB-1310" @default.
- NCIT_C200456 hasExactSynonym "Anti-HER3/Topoisomerase I Inhibitor ADC DB-1310" @default.
- NCIT_C200456 hasExactSynonym "Anti-HER3/Topoisomerase I Inhibitor Antibody-drug Conjugate DB-1310" @default.
- NCIT_C200456 hasExactSynonym "DB 1310" @default.
- NCIT_C200456 hasExactSynonym "DB-1310" @default.
- NCIT_C200456 hasExactSynonym "DB1310" @default.
- NCIT_C200456 inSubset NCIT_C116977 @default.
- NCIT_C200456 inSubset NCIT_C116978 @default.
- NCIT_C200456 inSubset NCIT_C128784 @default.
- NCIT_C200456 inSubset NCIT_C157711 @default.
- NCIT_C200456 inSubset NCIT_C157712 @default.
- NCIT_C200456 inSubset NCIT_C176424 @default.
- NCIT_C200456 type Class @default.
- NCIT_C200456 isDefinedBy ncit.owl @default.
- NCIT_C200456 label "Anti-HER3/Topoisomerase I Inhibitor Antibody-drug Conjugate DB-1310" @default.
- NCIT_C200456 subClassOf NCIT_C129821 @default.
- NCIT_C200456 subClassOf NCIT_C129823 @default.
- NCIT_C200456 subClassOf NCIT_C1512 @default.
- NCIT_C200456 subClassOf NCIT_C163758 @default.
- NCIT_C200456 subClassOf NCIT_C1908 @default.
- NCIT_C200456 subClassOf NCIT_C1909 @default.
- NCIT_C200456 subClassOf NCIT_C199383 @default.
- NCIT_C200456 subClassOf NCIT_C199385 @default.
- NCIT_C200456 subClassOf NCIT_C200456 @default.
- NCIT_C200456 subClassOf NCIT_C274 @default.
- NCIT_C200456 subClassOf NCIT_C307 @default.
- NCIT_C200456 subClassOf NCIT_C308 @default.