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- NCIT_C200457 IAO_0000115 "A polyepitope plasmid DNA therapeutic cancer vaccine containing the mammalian expression vector pUMVC3 encoding multiple epitopes derived from tumor-associated antigens (TAAs): human insulin-like growth factor-binding protein 2 (IGFBP2), with potential immunostimulating and antineoplastic activities. Upon intradermal vaccination, anti-IGFBP2 plasmid DNA vaccine AST-201 enters cells which process the plasmid, and express the epitopes and present them to antigen-presenting cells (APCs). This activates the immune system to mount a combined response from specific T-helper type 1 (Th1) cells, memory T-cells and cytotoxic T-lymphocytes (CTL) against IGFBP2-expressing tumor cells. IGFBP2, overexpressed in certain tumor cell types, plays a key role in cellular proliferation and survival." @default.
- NCIT_C200457 NCIT_A7 NCIT_C17506 @default.
- NCIT_C200457 NCIT_NHC0 "C200457" @default.
- NCIT_C200457 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200457 NCIT_P108 "Anti-IGFBP2 Plasmid DNA Vaccine AST-201" @default.
- NCIT_C200457 NCIT_P322 "GDC" @default.
- NCIT_C200457 NCIT_P399 "812846" @default.
- NCIT_C200457 normalizedInformationContent "100" @default.
- NCIT_C200457 referenceCount "1" @default.
- NCIT_C200457 hasExactSynonym "AST 201" @default.
- NCIT_C200457 hasExactSynonym "AST-201" @default.
- NCIT_C200457 hasExactSynonym "AST201" @default.
- NCIT_C200457 hasExactSynonym "Anti-IGFBP2 Plasmid DNA Vaccine AST-201" @default.
- NCIT_C200457 hasExactSynonym "IGFBP2 Vaccine AST201" @default.
- NCIT_C200457 hasExactSynonym "Therapeutic Cancer Vaccine AST-201" @default.
- NCIT_C200457 hasExactSynonym "pUMVC3-hIGFBP-2 Multi-epitope Plasmid DNA Vaccine AST201" @default.
- NCIT_C200457 hasExactSynonym "pUMVC3-hIGFBP-2-based Vaccine AST201" @default.
- NCIT_C200457 inSubset NCIT_C128784 @default.
- NCIT_C200457 inSubset NCIT_C157711 @default.
- NCIT_C200457 inSubset NCIT_C157712 @default.
- NCIT_C200457 inSubset NCIT_C176424 @default.
- NCIT_C200457 type Class @default.
- NCIT_C200457 isDefinedBy ncit.owl @default.
- NCIT_C200457 label "Anti-IGFBP2 Plasmid DNA Vaccine AST-201" @default.
- NCIT_C200457 subClassOf NCIT_C129820 @default.
- NCIT_C200457 subClassOf NCIT_C1663 @default.
- NCIT_C200457 subClassOf NCIT_C1908 @default.
- NCIT_C200457 subClassOf NCIT_C1909 @default.
- NCIT_C200457 subClassOf NCIT_C200457 @default.
- NCIT_C200457 subClassOf NCIT_C274 @default.
- NCIT_C200457 subClassOf NCIT_C307 @default.
- NCIT_C200457 subClassOf NCIT_C308 @default.
- NCIT_C200457 subClassOf NCIT_C39619 @default.
- NCIT_C200457 subClassOf NCIT_C923 @default.