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- NCIT_C200458 IAO_0000115 "A bispecific monoclonal antibody containing one arm targeting human CD3, a T-cell surface antigen that is part of the T-cell receptor (TCR) complex, and two arms targeting the membrane-proximal domain of the tumor-associated antigen (TAA) human mucin 16 (MUC16, cancer antigen 125; CA125; FLJ14303), with potential antineoplastic activity. Upon administration, anti-MUC16/anti-CD3 bispecific antibody LBL-033 binds to both T-cells and MUC16-expressing tumor cells, which cross-links the T-cells to the tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against the MUC16-expressing tumor cells. MUC16, a member of the mucin family of glycoproteins, is overexpressed on a variety of cancer cell types. BY binding in a 2:1 ratio to MUC16 and CD3, LBL-033 improves aggregation in MUC16-overexpressing tumor cells while reducing the non-specific activation of CD3. This may improve efficacy and minimize potential systemic toxicity, such as cytokine release syndrome (CRS)." @default.
- NCIT_C200458 NCIT_A7 NCIT_C71020 @default.
- NCIT_C200458 NCIT_NHC0 "C200458" @default.
- NCIT_C200458 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200458 NCIT_P108 "Anti-MUC16/Anti-CD3 Bispecific Antibody LBL-033" @default.
- NCIT_C200458 NCIT_P322 "GDC" @default.
- NCIT_C200458 NCIT_P399 "812845" @default.
- NCIT_C200458 NCIT_R124 NCIT_C17710 @default.
- NCIT_C200458 NCIT_R124 NCIT_C17828 @default.
- NCIT_C200458 NCIT_R124 NCIT_C18219 @default.
- NCIT_C200458 NCIT_R124 NCIT_C19986 @default.
- NCIT_C200458 NCIT_R124 NCIT_C40474 @default.
- NCIT_C200458 normalizedInformationContent "100" @default.
- NCIT_C200458 referenceCount "1" @default.
- NCIT_C200458 hasExactSynonym "Anti-MUC16/Anti-CD3 Bispecific Antibody LBL-033" @default.
- NCIT_C200458 hasExactSynonym "Anti-MUC16/CD3 Bispecific Antibody LBL-033" @default.
- NCIT_C200458 hasExactSynonym "LBL 033" @default.
- NCIT_C200458 hasExactSynonym "LBL-033" @default.
- NCIT_C200458 hasExactSynonym "LBL033" @default.
- NCIT_C200458 hasExactSynonym "T-cell Engager LBL-033" @default.
- NCIT_C200458 inSubset NCIT_C128784 @default.
- NCIT_C200458 inSubset NCIT_C157711 @default.
- NCIT_C200458 inSubset NCIT_C157712 @default.
- NCIT_C200458 inSubset NCIT_C176424 @default.
- NCIT_C200458 type Class @default.
- NCIT_C200458 isDefinedBy ncit.owl @default.
- NCIT_C200458 label "Anti-MUC16/Anti-CD3 Bispecific Antibody LBL-033" @default.
- NCIT_C200458 subClassOf NCIT_C112883 @default.
- NCIT_C200458 subClassOf NCIT_C129821 @default.
- NCIT_C200458 subClassOf NCIT_C129822 @default.
- NCIT_C200458 subClassOf NCIT_C1454 @default.
- NCIT_C200458 subClassOf NCIT_C1908 @default.
- NCIT_C200458 subClassOf NCIT_C1909 @default.
- NCIT_C200458 subClassOf NCIT_C200458 @default.
- NCIT_C200458 subClassOf NCIT_C201282 @default.
- NCIT_C200458 subClassOf NCIT_C20401 @default.
- NCIT_C200458 subClassOf NCIT_C274 @default.
- NCIT_C200458 subClassOf NCIT_C28227 @default.
- NCIT_C200458 subClassOf NCIT_C307 @default.
- NCIT_C200458 subClassOf NCIT_C308 @default.