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- NCIT_C200461 IAO_0000115 "An orally bioavailable chimeric degrader of Bruton's tyrosine kinase (BTK) comprised of an E3 ubiquitin ligase ligand conjugated to a BTK-binding ligand, with potential antineoplastic activity. Upon oral administration, BTK degrader AC0676 specifically targets and binds to, with its BTK-targeting moiety, wild-type (WT) and various mutant forms, including, but not limited to, C481S and L528W. Upon binding, the E3 ubiquitin ligase ligand moiety binds to E3 ubiquitin ligase. This catalyzes ubiquitination and proteasome-mediated degradation of BTK, and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival." @default.
- NCIT_C200461 NCIT_A7 NCIT_C75017 @default.
- NCIT_C200461 NCIT_NHC0 "C200461" @default.
- NCIT_C200461 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200461 NCIT_P108 "BTK Degrader AC0676" @default.
- NCIT_C200461 NCIT_P322 "GDC" @default.
- NCIT_C200461 NCIT_P399 "812850" @default.
- NCIT_C200461 normalizedInformationContent "100" @default.
- NCIT_C200461 referenceCount "1" @default.
- NCIT_C200461 hasExactSynonym "AC 0676" @default.
- NCIT_C200461 hasExactSynonym "AC-0676" @default.
- NCIT_C200461 hasExactSynonym "AC0676" @default.
- NCIT_C200461 hasExactSynonym "BTK Degrader AC0676" @default.
- NCIT_C200461 inSubset NCIT_C128784 @default.
- NCIT_C200461 inSubset NCIT_C157711 @default.
- NCIT_C200461 inSubset NCIT_C157712 @default.
- NCIT_C200461 inSubset NCIT_C176424 @default.
- NCIT_C200461 type Class @default.
- NCIT_C200461 isDefinedBy ncit.owl @default.
- NCIT_C200461 label "BTK Degrader AC0676" @default.
- NCIT_C200461 subClassOf NCIT_C124801 @default.
- NCIT_C200461 subClassOf NCIT_C1404 @default.
- NCIT_C200461 subClassOf NCIT_C163758 @default.
- NCIT_C200461 subClassOf NCIT_C163774 @default.
- NCIT_C200461 subClassOf NCIT_C1908 @default.
- NCIT_C200461 subClassOf NCIT_C1909 @default.
- NCIT_C200461 subClassOf NCIT_C1967 @default.
- NCIT_C200461 subClassOf NCIT_C200461 @default.
- NCIT_C200461 subClassOf NCIT_C274 @default.
- NCIT_C200461 subClassOf NCIT_C471 @default.