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- NCIT_C200462 IAO_0000115 "An orally bioavailable, mutant-selective, third-generation epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, EGFR mutant-selective inhibitor YK-029A targets, binds to and inhibits the activity of EGFR with exon 20 insertion (Ex20ins) activating mutations, the gatekeeper mutation T790M and some other rare mutations, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C200462 NCIT_A7 NCIT_C128663 @default.
- NCIT_C200462 NCIT_A7 NCIT_C98503 @default.
- NCIT_C200462 NCIT_NHC0 "C200462" @default.
- NCIT_C200462 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200462 NCIT_P108 "EGFR Mutant-selective Inhibitor YK-029A" @default.
- NCIT_C200462 NCIT_P322 "GDC" @default.
- NCIT_C200462 NCIT_P399 "812836" @default.
- NCIT_C200462 normalizedInformationContent "100" @default.
- NCIT_C200462 referenceCount "1" @default.
- NCIT_C200462 hasExactSynonym "EGFR Inhibitor YK-029A" @default.
- NCIT_C200462 hasExactSynonym "EGFR Mutant-selective Inhibitor YK-029A" @default.
- NCIT_C200462 hasExactSynonym "EGFR TKI Inhibitor YK-029A" @default.
- NCIT_C200462 hasExactSynonym "Mutant-selective EGFR Inhibitor YK-029A" @default.
- NCIT_C200462 hasExactSynonym "YK 029A" @default.
- NCIT_C200462 hasExactSynonym "YK-029A" @default.
- NCIT_C200462 hasExactSynonym "YK029A" @default.
- NCIT_C200462 inSubset NCIT_C128784 @default.
- NCIT_C200462 inSubset NCIT_C157711 @default.
- NCIT_C200462 inSubset NCIT_C157712 @default.
- NCIT_C200462 inSubset NCIT_C176424 @default.
- NCIT_C200462 type Class @default.
- NCIT_C200462 isDefinedBy ncit.owl @default.
- NCIT_C200462 label "EGFR Mutant-selective Inhibitor YK-029A" @default.
- NCIT_C200462 subClassOf NCIT_C129824 @default.
- NCIT_C200462 subClassOf NCIT_C129825 @default.
- NCIT_C200462 subClassOf NCIT_C1404 @default.
- NCIT_C200462 subClassOf NCIT_C163758 @default.
- NCIT_C200462 subClassOf NCIT_C163952 @default.
- NCIT_C200462 subClassOf NCIT_C1908 @default.
- NCIT_C200462 subClassOf NCIT_C1909 @default.
- NCIT_C200462 subClassOf NCIT_C1967 @default.
- NCIT_C200462 subClassOf NCIT_C199379 @default.
- NCIT_C200462 subClassOf NCIT_C200462 @default.
- NCIT_C200462 subClassOf NCIT_C2167 @default.
- NCIT_C200462 subClassOf NCIT_C2189 @default.
- NCIT_C200462 subClassOf NCIT_C274 @default.
- NCIT_C200462 subClassOf NCIT_C471 @default.