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- NCIT_C200464 IAO_0000115 "A radiotracer composed of RAD301, which comprises an integrin alphaVbeta6 (aVb6) binding peptide (BP) and is radiolabeled with the radionuclide gallium Ga 68, with potential integrin aVb6 imaging activity using positron emission tomography (PET). Upon administration of gallium Ga 68-labeled alphaVbeta6 binding peptide RAD301, the aVb6-binding peptide moiety selectively targets and binds to integrin aVb6-positive cancer cells. During PET, aVb6-expressing tumor cells can be visualized and the degree of tumor growth can be determined. Integrin aVb6, a cell adhesion and signaling receptor, is upregulated in certain cancer cell types and has been associated with increased proliferation, migration and invasion of tumor cells." @default.
- NCIT_C200464 NCIT_A7 NCIT_C124258 @default.
- NCIT_C200464 NCIT_NHC0 "C200464" @default.
- NCIT_C200464 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200464 NCIT_P108 "Gallium Ga 68-labeled alphaVbeta6 Binding Peptide RAD 301" @default.
- NCIT_C200464 NCIT_P322 "GDC" @default.
- NCIT_C200464 NCIT_P399 "812853" @default.
- NCIT_C200464 normalizedInformationContent "100" @default.
- NCIT_C200464 referenceCount "1" @default.
- NCIT_C200464 hasExactSynonym "68Ga-Trivehexin" @default.
- NCIT_C200464 hasExactSynonym "Gallium Ga 68 Trivehexin" @default.
- NCIT_C200464 hasExactSynonym "Gallium Ga 68-labeled alphaVbeta6 Binding Peptide RAD 301" @default.
- NCIT_C200464 hasExactSynonym "RAD 301" @default.
- NCIT_C200464 hasExactSynonym "RAD-301" @default.
- NCIT_C200464 hasExactSynonym "RAD301" @default.
- NCIT_C200464 hasExactSynonym "Radiotracer RAD 301" @default.
- NCIT_C200464 inSubset NCIT_C128784 @default.
- NCIT_C200464 inSubset NCIT_C157711 @default.
- NCIT_C200464 inSubset NCIT_C157712 @default.
- NCIT_C200464 inSubset NCIT_C176424 @default.
- NCIT_C200464 type Class @default.
- NCIT_C200464 isDefinedBy ncit.owl @default.
- NCIT_C200464 label "Gallium Ga 68-labeled alphaVbeta6 Binding Peptide RAD 301" @default.
- NCIT_C200464 subClassOf NCIT_C1446 @default.
- NCIT_C200464 subClassOf NCIT_C1511 @default.
- NCIT_C200464 subClassOf NCIT_C1512 @default.
- NCIT_C200464 subClassOf NCIT_C1908 @default.
- NCIT_C200464 subClassOf NCIT_C1909 @default.
- NCIT_C200464 subClassOf NCIT_C200464 @default.
- NCIT_C200464 subClassOf NCIT_C2124 @default.
- NCIT_C200464 subClassOf NCIT_C307 @default.
- NCIT_C200464 subClassOf NCIT_C308 @default.