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- NCIT_C200544 IAO_0000115 "A human, tetravalent, bispecific immunoglobulin G1 (IgG1)-single chain variable fragment (scFv) fusion antibody targeting both the tumor-associated antigen (TAA) CD123 and the human low affinity immunoglobulin G (IgG) Fc region receptor IIIA (FCGR3A; CD16A), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD123/CD16A bispecific antibody AFM28 simultaneously targets and binds to CD16A expressed on natural killer (NK) cells and macrophages, and to CD123 on CD123-expressing tumor cells, thereby selectively cross-linking CD123-expressing tumor cells with NK cells and macrophages. This may result in NK cell and macrophage activation, induce antibody-dependent cellular cytotoxicity (ADCC), and eventually causes tumor cell lysis. CD123 is overexpressed in a variety of hematological malignancies; its expression is low or absent in normal hematopoietic progenitors and stem cells. CD16A is specifically expressed on the surface of NK cells and macrophages." @default.
- NCIT_C200544 NCIT_NHC0 "C200544" @default.
- NCIT_C200544 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200544 NCIT_P108 "Anti-CD123/CD16A Bispecific Antibody AFM28" @default.
- NCIT_C200544 NCIT_P322 "GDC" @default.
- NCIT_C200544 NCIT_P399 "812989" @default.
- NCIT_C200544 NCIT_R124 NCIT_C17710 @default.
- NCIT_C200544 NCIT_R124 NCIT_C17828 @default.
- NCIT_C200544 NCIT_R124 NCIT_C18219 @default.
- NCIT_C200544 NCIT_R124 NCIT_C19986 @default.
- NCIT_C200544 NCIT_R124 NCIT_C40474 @default.
- NCIT_C200544 normalizedInformationContent "100" @default.
- NCIT_C200544 referenceCount "1" @default.
- NCIT_C200544 hasExactSynonym "AFM 28" @default.
- NCIT_C200544 hasExactSynonym "AFM-28" @default.
- NCIT_C200544 hasExactSynonym "AFM28" @default.
- NCIT_C200544 hasExactSynonym "Anti-CD123/CD16A Bispecific Antibody AFM28" @default.
- NCIT_C200544 hasExactSynonym "Bispecific Antibody Anti-CD123/Anti-CD16A AFM28" @default.
- NCIT_C200544 hasExactSynonym "Bispecific Innate Cell Engager AFM28" @default.
- NCIT_C200544 hasExactSynonym "ICE AFM28" @default.
- NCIT_C200544 inSubset NCIT_C157711 @default.
- NCIT_C200544 inSubset NCIT_C157712 @default.
- NCIT_C200544 inSubset NCIT_C176424 @default.
- NCIT_C200544 type Class @default.
- NCIT_C200544 isDefinedBy ncit.owl @default.
- NCIT_C200544 label "Anti-CD123/CD16A Bispecific Antibody AFM28" @default.
- NCIT_C200544 subClassOf NCIT_C129821 @default.
- NCIT_C200544 subClassOf NCIT_C129822 @default.
- NCIT_C200544 subClassOf NCIT_C1454 @default.
- NCIT_C200544 subClassOf NCIT_C1908 @default.
- NCIT_C200544 subClassOf NCIT_C1909 @default.
- NCIT_C200544 subClassOf NCIT_C200544 @default.
- NCIT_C200544 subClassOf NCIT_C201511 @default.
- NCIT_C200544 subClassOf NCIT_C20401 @default.
- NCIT_C200544 subClassOf NCIT_C274 @default.
- NCIT_C200544 subClassOf NCIT_C307 @default.
- NCIT_C200544 subClassOf NCIT_C308 @default.