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- NCIT_C200545 IAO_0000115 "A human immunoglobulin G4 (IgG4) agonistic monoclonal antibody directed against the inducible T‐cell costimulatory receptor CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD137 monoclonal antibody PE0116 is selectively activated in the tumor microenvironment (TME), and targets, binds to, crosslinks and activates CD137 expressed on a variety of leukocyte subsets including activated T-lymphocytes and natural killer (NK) cells. This enhances CD137-mediated signaling, induces T-cell proliferation, cytokine production and promotes T-cell mediated anti-tumor immune responses. CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity to promote anti-tumor immunity." @default.
- NCIT_C200545 NCIT_A7 NCIT_C105113 @default.
- NCIT_C200545 NCIT_NHC0 "C200545" @default.
- NCIT_C200545 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200545 NCIT_P108 "Anti-CD137 Monoclonal Antibody PE0116" @default.
- NCIT_C200545 NCIT_P322 "GDC" @default.
- NCIT_C200545 NCIT_P399 "812987" @default.
- NCIT_C200545 NCIT_R124 NCIT_C17710 @default.
- NCIT_C200545 NCIT_R124 NCIT_C17828 @default.
- NCIT_C200545 NCIT_R124 NCIT_C18219 @default.
- NCIT_C200545 NCIT_R124 NCIT_C19986 @default.
- NCIT_C200545 NCIT_R124 NCIT_C40474 @default.
- NCIT_C200545 normalizedInformationContent "100" @default.
- NCIT_C200545 referenceCount "1" @default.
- NCIT_C200545 hasExactSynonym "Anti-4-1BB Monoclonal Antibody PE0116" @default.
- NCIT_C200545 hasExactSynonym "Anti-CD137 Monoclonal Antibody PE0116" @default.
- NCIT_C200545 hasExactSynonym "PE 0116" @default.
- NCIT_C200545 hasExactSynonym "PE-0116" @default.
- NCIT_C200545 hasExactSynonym "PE0116" @default.
- NCIT_C200545 inSubset NCIT_C157711 @default.
- NCIT_C200545 inSubset NCIT_C157712 @default.
- NCIT_C200545 inSubset NCIT_C176424 @default.
- NCIT_C200545 type Class @default.
- NCIT_C200545 isDefinedBy ncit.owl @default.
- NCIT_C200545 label "Anti-CD137 Monoclonal Antibody PE0116" @default.
- NCIT_C200545 subClassOf NCIT_C129820 @default.
- NCIT_C200545 subClassOf NCIT_C155745 @default.
- NCIT_C200545 subClassOf NCIT_C1908 @default.
- NCIT_C200545 subClassOf NCIT_C1909 @default.
- NCIT_C200545 subClassOf NCIT_C192997 @default.
- NCIT_C200545 subClassOf NCIT_C200545 @default.
- NCIT_C200545 subClassOf NCIT_C20401 @default.
- NCIT_C200545 subClassOf NCIT_C274 @default.
- NCIT_C200545 subClassOf NCIT_C307 @default.
- NCIT_C200545 subClassOf NCIT_C308 @default.