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- NCIT_C200547 IAO_0000115 "A humanized monoclonal antibody directed against the transforming growth factor beta (TGFbeta) activator glycoprotein A repetitions predominant (GARP; leucine-rich repeat-containing protein 32; LRRC32), with potential immunomodulating and antineoplastic activities. Upon administration, anti-GARP monoclonal antibody JYB1907 selectively targets and binds to GARP. This specifically blocks the GARP-mediated release of the cytokine transforming growth factor-beta 1 (TGF-b1), thereby relieving the immunosuppression caused by TGF-b1 and reversing the immunosuppressive nature in the tumor microenvironment (TME). This improves anti-tumor immune responses GARP, a transmembrane protein highly expressed on activated, immunosuppressive regulatory T-cells (Tregs) in the TME, is essential for the expression of TGF-b1 on the cell surface of activated Tregs; it plays an important role in regulation of the immune cell function and the immunosuppressive nature of Tregs. TGF-b1 stimulates stromal cell proliferation, neovascularization, cancer cell metastasis, and inhibits immune cell infiltration." @default.
- NCIT_C200547 NCIT_A7 NCIT_C106014 @default.
- NCIT_C200547 NCIT_NHC0 "C200547" @default.
- NCIT_C200547 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200547 NCIT_P108 "Anti-GARP Monoclonal Antibody JYB1907" @default.
- NCIT_C200547 NCIT_P322 "GDC" @default.
- NCIT_C200547 NCIT_P399 "812926" @default.
- NCIT_C200547 NCIT_R124 NCIT_C17710 @default.
- NCIT_C200547 NCIT_R124 NCIT_C17828 @default.
- NCIT_C200547 NCIT_R124 NCIT_C18219 @default.
- NCIT_C200547 NCIT_R124 NCIT_C19986 @default.
- NCIT_C200547 NCIT_R124 NCIT_C40474 @default.
- NCIT_C200547 normalizedInformationContent "100" @default.
- NCIT_C200547 referenceCount "1" @default.
- NCIT_C200547 hasExactSynonym "Anti-GARP Monoclonal Antibody JYB1907" @default.
- NCIT_C200547 hasExactSynonym "Anti-glycoprotein A Repetitions Predominant Monoclonal Antibody JYB1907" @default.
- NCIT_C200547 hasExactSynonym "JYB 1907" @default.
- NCIT_C200547 hasExactSynonym "JYB-1907" @default.
- NCIT_C200547 hasExactSynonym "JYB1907" @default.
- NCIT_C200547 inSubset NCIT_C157711 @default.
- NCIT_C200547 inSubset NCIT_C157712 @default.
- NCIT_C200547 inSubset NCIT_C176424 @default.
- NCIT_C200547 type Class @default.
- NCIT_C200547 isDefinedBy ncit.owl @default.
- NCIT_C200547 label "Anti-GARP Monoclonal Antibody JYB1907" @default.
- NCIT_C200547 subClassOf NCIT_C129821 @default.
- NCIT_C200547 subClassOf NCIT_C129822 @default.
- NCIT_C200547 subClassOf NCIT_C1908 @default.
- NCIT_C200547 subClassOf NCIT_C1909 @default.
- NCIT_C200547 subClassOf NCIT_C200547 @default.
- NCIT_C200547 subClassOf NCIT_C201536 @default.
- NCIT_C200547 subClassOf NCIT_C20401 @default.
- NCIT_C200547 subClassOf NCIT_C274 @default.
- NCIT_C200547 subClassOf NCIT_C307 @default.
- NCIT_C200547 subClassOf NCIT_C308 @default.