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- NCIT_C200558 IAO_0000115 "A genetically engineered oncolytic vaccinia viral (VV) vector expressing the human immunostimulating cytokine interleukin-12 (IL-12) and a full-length antibody directed against the human inhibitory T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4; CTLA4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intavenous administration, IL-12/anti-CTLA-4 monoclonal antibody-expressing oncolytic VV TG6050 specifically infects and replicates in tumor cells causing viral-mediated tumor cell lysis. The released virus particles, in turn, infect and replicate in neighboring tumor cells, thereby further killing tumor cells. Tumor antigens released from the lysed tumor cells also activate the immune system to induce a tumor-specific systemic immune and cytotoxic T-lymphocyte (CTL) response, thereby killing nearby non-infected tumor cells. In addition, the expression of IL-12 promotes the activation of natural killer (NK) cells, which induces the secretion of interferon-gamma and a CTL-mediated response against uninfected tumor cells. This results in immune-mediated tumor cell death and further inhibition of tumor cell proliferation. The anti-CTLA-4 antibody released by the infected cells targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation, which promotes T-cell activation and further enhances a CTL-mediated anti-tumor immune response. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system." @default.
- NCIT_C200558 NCIT_A7 NCIT_C17489 @default.
- NCIT_C200558 NCIT_A7 NCIT_C38917 @default.
- NCIT_C200558 NCIT_A7 NCIT_C38919 @default.
- NCIT_C200558 NCIT_NHC0 "C200558" @default.
- NCIT_C200558 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200558 NCIT_P106 "Virus" @default.
- NCIT_C200558 NCIT_P108 "IL-12/Anti-CTLA-4 Monoclonal Antibody-expressing Oncolytic Viral Vector TG6050" @default.
- NCIT_C200558 NCIT_P322 "GDC" @default.
- NCIT_C200558 NCIT_P399 "812919" @default.
- NCIT_C200558 normalizedInformationContent "100" @default.
- NCIT_C200558 referenceCount "1" @default.
- NCIT_C200558 hasExactSynonym "IL-12/Anti-CTLA-4 Monoclonal Antibody-expressing Oncolytic VV TG6050" @default.
- NCIT_C200558 hasExactSynonym "IL-12/Anti-CTLA-4 Monoclonal Antibody-expressing Oncolytic Viral Vector TG6050" @default.
- NCIT_C200558 hasExactSynonym "Oncolytic Vaccinia Virus Expressing IL-12/Anti-CTLA4 Antibody TG6050" @default.
- NCIT_C200558 hasExactSynonym "TG 6050" @default.
- NCIT_C200558 hasExactSynonym "TG- 6050" @default.
- NCIT_C200558 hasExactSynonym "TG6050" @default.
- NCIT_C200558 hasExactSynonym "VV-expressing IL-12/Anti-CTLA4 Antibody TG6050" @default.
- NCIT_C200558 inSubset NCIT_C157711 @default.
- NCIT_C200558 inSubset NCIT_C157712 @default.
- NCIT_C200558 inSubset NCIT_C176424 @default.
- NCIT_C200558 type Class @default.
- NCIT_C200558 isDefinedBy ncit.owl @default.
- NCIT_C200558 label "IL-12/Anti-CTLA-4 Monoclonal Antibody-expressing Oncolytic Viral Vector TG6050" @default.
- NCIT_C200558 subClassOf NCIT_C129821 @default.
- NCIT_C200558 subClassOf NCIT_C1908 @default.
- NCIT_C200558 subClassOf NCIT_C1909 @default.
- NCIT_C200558 subClassOf NCIT_C200558 @default.
- NCIT_C200558 subClassOf NCIT_C274 @default.
- NCIT_C200558 subClassOf NCIT_C307 @default.
- NCIT_C200558 subClassOf NCIT_C717 @default.