Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C200560> ?p ?o ?g. }
Showing items 1 to 31 of
31
with 100 items per page.
- NCIT_C200560 IAO_0000115 "An engineered tri-specific natural killer (NK) cell engager (NKCE) containing specific antibodies targeting the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), and the NK activating receptors natural cytotoxicity triggering receptor (NKp46; activating natural killer receptor p46) and CD16, with potential immunostimulating and antineoplastic activities. Upon administration of NKp46/CD16-based BCMA-targeted NK cell engager SAR445514, the NKCE targets and binds to BCMA expressed on tumor cells and simultaneously binds, via the activating receptors NKp46 and CD16, to NK cells, thereby bringing BCMA-expressing tumor cells and NK cells together. This stimulates the NK cells and results in the selective NK cell-mediated tumor cell lysis of BCMA-expressing tumor cells. BCMA, a tumor-specific antigen and a member of the tumor necrosis factor receptor superfamily (TNFRSF) that binds to both a proliferation-inducing ligand (APRIL; TNFSF13) and B-cell activating factor (BAFF; TNFSF13B), plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells." @default.
- NCIT_C200560 NCIT_A7 NCIT_C97848 @default.
- NCIT_C200560 NCIT_NHC0 "C200560" @default.
- NCIT_C200560 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200560 NCIT_P108 "NKp46/CD16-based BCMA-targeted NK Cell Engager SAR445514" @default.
- NCIT_C200560 NCIT_P322 "GDC" @default.
- NCIT_C200560 NCIT_P399 "813052" @default.
- NCIT_C200560 normalizedInformationContent "100" @default.
- NCIT_C200560 referenceCount "1" @default.
- NCIT_C200560 hasExactSynonym "Anti-BCMA NKp46xCD16 NK Cell Engager SAR445514" @default.
- NCIT_C200560 hasExactSynonym "BCMA-targeting NK Cell Engager SAR445514" @default.
- NCIT_C200560 hasExactSynonym "IPH 6401" @default.
- NCIT_C200560 hasExactSynonym "IPH-6401" @default.
- NCIT_C200560 hasExactSynonym "IPH6401" @default.
- NCIT_C200560 hasExactSynonym "NKp46/CD16-based BCMA-targeted NK Cell Engager IPH6401" @default.
- NCIT_C200560 hasExactSynonym "NKp46/CD16-based BCMA-targeted NK Cell Engager SAR445514" @default.
- NCIT_C200560 hasExactSynonym "SAR 445514" @default.
- NCIT_C200560 hasExactSynonym "SAR-445514" @default.
- NCIT_C200560 hasExactSynonym "SAR445514" @default.
- NCIT_C200560 inSubset NCIT_C157711 @default.
- NCIT_C200560 inSubset NCIT_C157712 @default.
- NCIT_C200560 inSubset NCIT_C176424 @default.
- NCIT_C200560 type Class @default.
- NCIT_C200560 isDefinedBy ncit.owl @default.
- NCIT_C200560 label "NKp46/CD16-based BCMA-targeted NK Cell Engager SAR445514" @default.
- NCIT_C200560 subClassOf NCIT_C129820 @default.
- NCIT_C200560 subClassOf NCIT_C1908 @default.
- NCIT_C200560 subClassOf NCIT_C1909 @default.
- NCIT_C200560 subClassOf NCIT_C200560 @default.
- NCIT_C200560 subClassOf NCIT_C274 @default.
- NCIT_C200560 subClassOf NCIT_C308 @default.