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- NCIT_C200752 IAO_0000115 "Complement C1r subcomponent (705 aa, ~80 kDa) is encoded by the human C1R gene. This protein is involved in the proteolytic activation of complement C1s subcomponent." @default.
- NCIT_C200752 NCIT_NHC0 "C200752" @default.
- NCIT_C200752 NCIT_P100 "613785" @default.
- NCIT_C200752 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C200752 NCIT_P106 "Enzyme" @default.
- NCIT_C200752 NCIT_P108 "Complement C1r Subcomponent" @default.
- NCIT_C200752 NCIT_P93 "P00736" @default.
- NCIT_C200752 NCIT_P98 "Complement C1 complex is composed of 1 molecule of C1q, 2 molecules of C1r and 2 molecules of C1s. When antigen-antibody complexes, pentraxins or pathogens bind C1q, its conformation changes and causes activation of C1r. Active C1r cleaves C1s into A (heavy) and B (light) chains. The C1s B chain contains the active site that cleaves an Arg-/-Ala bond in complement component C4 to form C4a and C4b, and a Lys(or Arg)-/-Lys bond in complement component C2 to form C2a and C2b. (UniProt)" @default.
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- NCIT_C200752 normalizedInformationContent "100" @default.
- NCIT_C200752 referenceCount "1" @default.
- NCIT_C200752 hasExactSynonym "C1R" @default.
- NCIT_C200752 hasExactSynonym "Complement C1r Subcomponent" @default.
- NCIT_C200752 hasExactSynonym "Complement C1r" @default.
- NCIT_C200752 hasExactSynonym "Complement Component 1 Subcomponent R" @default.
- NCIT_C200752 hasExactSynonym "EC 3.4.21.41" @default.
- NCIT_C200752 type Class @default.
- NCIT_C200752 isDefinedBy ncit.owl @default.
- NCIT_C200752 label "Complement C1r Subcomponent" @default.
- NCIT_C200752 subClassOf NCIT_C16554 @default.
- NCIT_C200752 subClassOf NCIT_C16701 @default.
- NCIT_C200752 subClassOf NCIT_C16965 @default.
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- NCIT_C200752 equivalentClass B480a422b764223d08679969848642873 @default.
- NCIT_C200752 equivalentClass Bacd3d2ffbb3332aaaf3c8900a6f38e62 @default.