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- NCIT_C20077 IAO_0000115 "v-sis Platelet Derived Growth Factor beta polypeptide is the viral homologue of PDGFB. Viral oncogenes originate from normal cellular genes by recombination between a parent nontransforming virus and host cellular DNA; the cellular genes often code for important functions in cell growth or tissue differentiation. PDGF is the major serum polypeptide mitogen for cells of mesenchymal origin and has two dissimilar subunits, A and B. The B chain has homology to SIS and is alone sufficient for mitogenesis. Most proliferating cells are programmed to undergo apoptosis unless specific survival signals are provided. PDGF promotes proliferation and inhibits apoptosis by activating the RAS/PIK3/AKT1/IKK/NFKB1 pathway, inducing putative anti-apoptotic genes. (from OMIM 190040 and NCI)" @default.
- NCIT_C20077 NCIT_NHC0 "C20077" @default.
- NCIT_C20077 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C20077 NCIT_P108 "v-sis Platelet Derived Growth Factor, Beta Polypeptide" @default.
- NCIT_C20077 NCIT_P207 "C1337057" @default.
- NCIT_C20077 NCIT_P366 "v-sis_PDGF_Beta_Polypeptide" @default.
- NCIT_C20077 NCIT_R45 NCIT_C14250 @default.
- NCIT_C20077 NCIT_R45 NCIT_C14283 @default.
- NCIT_C20077 NCIT_R54 NCIT_C16612 @default.
- NCIT_C20077 NCIT_R54 NCIT_C16620 @default.
- NCIT_C20077 NCIT_R54 NCIT_C20157 @default.
- NCIT_C20077 normalizedInformationContent "100" @default.
- NCIT_C20077 referenceCount "1" @default.
- NCIT_C20077 hasExactSynonym "v-sis Platelet Derived Growth Factor, Beta Polypeptide" @default.
- NCIT_C20077 type Class @default.
- NCIT_C20077 isDefinedBy ncit.owl @default.
- NCIT_C20077 label "v-sis Platelet Derived Growth Factor, Beta Polypeptide" @default.
- NCIT_C20077 subClassOf NCIT_C17021 @default.
- NCIT_C20077 subClassOf NCIT_C17254 @default.
- NCIT_C20077 subClassOf NCIT_C20032 @default.
- NCIT_C20077 subClassOf NCIT_C20077 @default.
- NCIT_C20077 subClassOf NCIT_C20158 @default.
- NCIT_C20077 subClassOf NCIT_C26548 @default.