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- NCIT_C200799 IAO_0000115 "A recombinant, immunoglobulin G1 (IgG1) bispecific antibody directed against both the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18) and the human cell surface antigen CD47, with potential immunostimulating, phagocytosis-inducing and antineoplastic activities. Upon administration of anti-CLDN18.2/CD47 bispecific antibody SG1906, the anti-CLDN18.2 moiety selectively targets and binds to CLDN18.2 on CLDN18.2-expressing tumor cells, thereby improving the binding of the anti-CD47 moiety to the CLDN18.2-expressing tumor cells. The CD47 binding by SG1906 blocks the interaction of CD47 with signal regulatory protein alpha (SIRPalpha), an inhibitory protein expressed on macrophages and dendritic cells (DCs), which prevents CD47/SIRPalpha-mediated signaling and abrogates the CD47/SIRPalpha-mediated inhibition of phagocytosis. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein (LRP), expressed on macrophages, which results in macrophage activation and the specific phagocytosis of the CLDN18.2-expressing tumor cells. Additionally, blocking CD47 signaling activates an anti-tumor T-lymphocyte immune response and T-cell-mediated killing of CLDN18.2-expressing tumor cells. CD47, also called integrin-associated protein (IAP), is widely expressed on normal, healthy cells, such as red blood cells (RBCs) and platelets, and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPalpha, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, which allows cancer cells to proliferate. CLDN18.2, a tight junction protein and stomach-specific isoform of Claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa. Co-targeting CD47 and CLDN18.2 may limit the binding of SG1906 to CD47 on healthy hematopoietic stem cells (HSCs) and may minimize any associated adverse effects." @default.
- NCIT_C200799 NCIT_NHC0 "C200799" @default.
- NCIT_C200799 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200799 NCIT_P108 "Anti-CLDN18.2/CD47 Bispecific Antibody SG1906" @default.
- NCIT_C200799 NCIT_P322 "GDC" @default.
- NCIT_C200799 NCIT_P399 "813118" @default.
- NCIT_C200799 NCIT_R124 NCIT_C17710 @default.
- NCIT_C200799 NCIT_R124 NCIT_C17828 @default.
- NCIT_C200799 NCIT_R124 NCIT_C18219 @default.
- NCIT_C200799 NCIT_R124 NCIT_C19986 @default.
- NCIT_C200799 NCIT_R124 NCIT_C40474 @default.
- NCIT_C200799 normalizedInformationContent "100" @default.
- NCIT_C200799 referenceCount "1" @default.
- NCIT_C200799 hasExactSynonym "Anti-CD47/Anti-CLDN18.2 Bispecific Antibody SG1906" @default.
- NCIT_C200799 hasExactSynonym "Anti-CLDN18.2/Anti-CD47 Bispecific Antibody SG1906" @default.
- NCIT_C200799 hasExactSynonym "Anti-CLDN18.2/CD47 Bispecific Antibody SG1906" @default.
- NCIT_C200799 hasExactSynonym "Anti-Claudin18.2/CD47 Bispecific Antibody SG1906" @default.
- NCIT_C200799 hasExactSynonym "CLDN18.2 x CD47 Bispecific Antibody SG1906" @default.
- NCIT_C200799 hasExactSynonym "SG 1906" @default.
- NCIT_C200799 hasExactSynonym "SG-1906" @default.
- NCIT_C200799 hasExactSynonym "SG1906" @default.
- NCIT_C200799 inSubset NCIT_C128784 @default.
- NCIT_C200799 inSubset NCIT_C157711 @default.
- NCIT_C200799 inSubset NCIT_C157712 @default.
- NCIT_C200799 inSubset NCIT_C176424 @default.
- NCIT_C200799 type Class @default.
- NCIT_C200799 isDefinedBy ncit.owl @default.
- NCIT_C200799 label "Anti-CLDN18.2/CD47 Bispecific Antibody SG1906" @default.
- NCIT_C200799 subClassOf NCIT_C129821 @default.
- NCIT_C200799 subClassOf NCIT_C129822 @default.
- NCIT_C200799 subClassOf NCIT_C1454 @default.
- NCIT_C200799 subClassOf NCIT_C159583 @default.
- NCIT_C200799 subClassOf NCIT_C163758 @default.
- NCIT_C200799 subClassOf NCIT_C179676 @default.
- NCIT_C200799 subClassOf NCIT_C1908 @default.
- NCIT_C200799 subClassOf NCIT_C1909 @default.
- NCIT_C200799 subClassOf NCIT_C192655 @default.
- NCIT_C200799 subClassOf NCIT_C200250 @default.
- NCIT_C200799 subClassOf NCIT_C200799 @default.
- NCIT_C200799 subClassOf NCIT_C20401 @default.
- NCIT_C200799 subClassOf NCIT_C274 @default.
- NCIT_C200799 subClassOf NCIT_C307 @default.
- NCIT_C200799 subClassOf NCIT_C308 @default.