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- NCIT_C200820 IAO_0000115 "An orally bioavailable inhibitor of the alpha-isoenzyme of diacylglycerol kinase (DGK alpha; DGKa), with potential immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, DGKa inhibitor BAY 2862789 targets, binds to and blocks DGKa expressed on T-cells, thereby preventing the conversion of diacylglycerol (DAG) to phosphatidic acid (PA). This induces DAG-mediated T-cell receptor (TCR)-mediated T-cell signaling, induces T-cell proliferation, restores T-cell function, enhances cytokine production, and activates a cytotoxic T-cell-mediated anti-tumor immune response. This induces apoptosis and suppresses proliferation of susceptible tumor cells. DGKa is involved in the negative regulation of second messenger signaling through lipid phosphorylation. DGKa is highly expressed in various cancers and promotes cancer cell survival through its antiapoptosis and proproliferation activities. Also highly expressed in T-lymphocytes, DGKa regulates TCR signaling, promotes T-cell anergy, and plays a key role in the downregulating of T-cell responses in tumors." @default.
- NCIT_C200820 NCIT_A7 NCIT_C112503 @default.
- NCIT_C200820 NCIT_NHC0 "C200820" @default.
- NCIT_C200820 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200820 NCIT_P108 "DGKalpha Inhibitor BAY 2862789" @default.
- NCIT_C200820 NCIT_P322 "GDC" @default.
- NCIT_C200820 NCIT_P399 "813137" @default.
- NCIT_C200820 normalizedInformationContent "100" @default.
- NCIT_C200820 referenceCount "1" @default.
- NCIT_C200820 hasExactSynonym "BAY 2862789" @default.
- NCIT_C200820 hasExactSynonym "BAY-2862789" @default.
- NCIT_C200820 hasExactSynonym "BAY2862789" @default.
- NCIT_C200820 hasExactSynonym "DGKa Inhibitor BAY 2862789" @default.
- NCIT_C200820 hasExactSynonym "DGKalpha Inhibitor BAY 2862789" @default.
- NCIT_C200820 hasExactSynonym "Diacylglycerol Kinase Alpha Inhibitor BAY 2862789" @default.
- NCIT_C200820 inSubset NCIT_C128784 @default.
- NCIT_C200820 inSubset NCIT_C157711 @default.
- NCIT_C200820 inSubset NCIT_C157712 @default.
- NCIT_C200820 inSubset NCIT_C176424 @default.
- NCIT_C200820 type Class @default.
- NCIT_C200820 isDefinedBy ncit.owl @default.
- NCIT_C200820 label "DGKalpha Inhibitor BAY 2862789" @default.
- NCIT_C200820 subClassOf NCIT_C129824 @default.
- NCIT_C200820 subClassOf NCIT_C129825 @default.
- NCIT_C200820 subClassOf NCIT_C1908 @default.
- NCIT_C200820 subClassOf NCIT_C1909 @default.
- NCIT_C200820 subClassOf NCIT_C200820 @default.
- NCIT_C200820 subClassOf NCIT_C201056 @default.
- NCIT_C200820 subClassOf NCIT_C2189 @default.
- NCIT_C200820 subClassOf NCIT_C274 @default.
- NCIT_C200820 subClassOf NCIT_C471 @default.