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- NCIT_C200823 IAO_0000115 "An orally bioavailable inhibitor of the extracellular signal-regulated kinases 1 (ERK1) and 2 (ERK2), with potential antineoplastic activity. Upon oral administration, ERK1/2 inhibitor D3S-002 specifically binds to and inhibits the serine/threonine-protein kinase activities of both ERK1 and ERK2, thereby preventing the phosphorylation of ERK1/2 substrates and the activation of mitogen-activated protein kinase (MAPK)/ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent proliferation and survival of tumor cells. The MAPK/ERK pathway, also known as the RAS/RAF/MEK/ERK pathway, is hyperactivated in a variety of tumor cell types due to mutations in upstream targets. It plays a key role in the proliferation, differentiation and survival of tumor cells." @default.
- NCIT_C200823 NCIT_A7 NCIT_C17408 @default.
- NCIT_C200823 NCIT_A7 NCIT_C17589 @default.
- NCIT_C200823 NCIT_NHC0 "C200823" @default.
- NCIT_C200823 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200823 NCIT_P108 "ERK1/2 Inhibitor D3S-002" @default.
- NCIT_C200823 NCIT_P322 "GDC" @default.
- NCIT_C200823 NCIT_P399 "813169" @default.
- NCIT_C200823 normalizedInformationContent "100" @default.
- NCIT_C200823 referenceCount "1" @default.
- NCIT_C200823 hasExactSynonym "D3S 002" @default.
- NCIT_C200823 hasExactSynonym "D3S-002" @default.
- NCIT_C200823 hasExactSynonym "D3S002" @default.
- NCIT_C200823 hasExactSynonym "ERK Inhibitor D3S-002" @default.
- NCIT_C200823 hasExactSynonym "ERK1/2 Inhibitor D3S-002" @default.
- NCIT_C200823 inSubset NCIT_C128784 @default.
- NCIT_C200823 inSubset NCIT_C157711 @default.
- NCIT_C200823 inSubset NCIT_C157712 @default.
- NCIT_C200823 inSubset NCIT_C176424 @default.
- NCIT_C200823 type Class @default.
- NCIT_C200823 isDefinedBy ncit.owl @default.
- NCIT_C200823 label "ERK1/2 Inhibitor D3S-002" @default.
- NCIT_C200823 subClassOf NCIT_C129824 @default.
- NCIT_C200823 subClassOf NCIT_C129825 @default.
- NCIT_C200823 subClassOf NCIT_C1404 @default.
- NCIT_C200823 subClassOf NCIT_C174048 @default.
- NCIT_C200823 subClassOf NCIT_C1908 @default.
- NCIT_C200823 subClassOf NCIT_C1909 @default.
- NCIT_C200823 subClassOf NCIT_C200823 @default.
- NCIT_C200823 subClassOf NCIT_C2189 @default.
- NCIT_C200823 subClassOf NCIT_C274 @default.
- NCIT_C200823 subClassOf NCIT_C471 @default.
- NCIT_C200823 subClassOf NCIT_C61074 @default.