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- NCIT_C200827 IAO_0000115 "A long-acting, extended-release (ER) microsphere formulation of the acetate form of goserelin, a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH), with potential antineoplastic activity. Upon administration of goserelin acetate ER microspheres LY01022, goserelin is released over an extended period of time and binds to and activates pituitary gonadotropin-releasing hormone (GnRH) receptors. Prolonged administration of goserelin inhibits the secretion of pituitary gonadotropin, thereby decreasing levels of testosterone (in males) and estradiol (in females). Administration of the goserelin ER formulation may result in the regression of sex hormone-sensitive tumors and a reduction in sex organ size and function. LY01022 prolongs the dosing cycle to a three-month period, thereby reducing the frequency of injections and potentially improving compliance." @default.
- NCIT_C200827 NCIT_NHC0 "C200827" @default.
- NCIT_C200827 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200827 NCIT_P108 "Goserelin Acetate Extended-release Microspheres LY01022" @default.
- NCIT_C200827 NCIT_P322 "GDC" @default.
- NCIT_C200827 NCIT_P399 "813117" @default.
- NCIT_C200827 normalizedInformationContent "100" @default.
- NCIT_C200827 referenceCount "1" @default.
- NCIT_C200827 hasExactSynonym "Goserelin Acetate ER Microspheres LY01022" @default.
- NCIT_C200827 hasExactSynonym "Goserelin Acetate Extended-release Microspheres LY01022" @default.
- NCIT_C200827 hasExactSynonym "Goserelin Acetate SR Microspheres LY01022" @default.
- NCIT_C200827 hasExactSynonym "Goserelin Acetate Sustained-release Microspheres LY01022" @default.
- NCIT_C200827 hasExactSynonym "LY 01022" @default.
- NCIT_C200827 hasExactSynonym "LY-01022" @default.
- NCIT_C200827 hasExactSynonym "LY01022" @default.
- NCIT_C200827 hasExactSynonym "Long-acting Goserelin Microspheres LY01022" @default.
- NCIT_C200827 inSubset NCIT_C128784 @default.
- NCIT_C200827 inSubset NCIT_C157711 @default.
- NCIT_C200827 inSubset NCIT_C157712 @default.
- NCIT_C200827 inSubset NCIT_C176424 @default.
- NCIT_C200827 type Class @default.
- NCIT_C200827 isDefinedBy ncit.owl @default.
- NCIT_C200827 label "Goserelin Acetate Extended-release Microspheres LY01022" @default.
- NCIT_C200827 subClassOf NCIT_C147908 @default.
- NCIT_C200827 subClassOf NCIT_C1908 @default.
- NCIT_C200827 subClassOf NCIT_C1909 @default.
- NCIT_C200827 subClassOf NCIT_C1910 @default.
- NCIT_C200827 subClassOf NCIT_C200827 @default.
- NCIT_C200827 subClassOf NCIT_C548 @default.