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- NCIT_C200910 IAO_0000115 "An oncolytic virus derived from the vesicular stomatitis virus (VSV), a single-stranded RNA virus, and containing a genetically modified glycoprotein (GP) and a human CD80 (B7.1) Fc fragment, with potential immunomodulating and antineoplastic activities. Upon administration, oncolytic VSV-GP BI 1821736 preferentially replicates in tumor cells, and induces VSV-mediated cytolytic activity towards the tumor cells. Viral infection also stimulates the immune system to recognize these same tumor cells, leading to immune-mediated killing of both infected and non-infected tumor cells, thereby further killing tumor cells. In addition, BI 1821736 secretes CD80, which targets and binds to CD28, and in the presence of antigenic T-cell receptor (TCR) signaling leads to the co-stimulation of T-cell responses including the activation of naive and memory T-cells. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells, thereby killing cancer cells." @default.
- NCIT_C200910 NCIT_NHC0 "C200910" @default.
- NCIT_C200910 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200910 NCIT_P106 "Virus" @default.
- NCIT_C200910 NCIT_P108 "Oncolytic VSV-GP BI 1821736" @default.
- NCIT_C200910 NCIT_P322 "GDC" @default.
- NCIT_C200910 NCIT_P399 "813114" @default.
- NCIT_C200910 normalizedInformationContent "100" @default.
- NCIT_C200910 referenceCount "1" @default.
- NCIT_C200910 hasExactSynonym "BI 1821736" @default.
- NCIT_C200910 hasExactSynonym "BI-1821736" @default.
- NCIT_C200910 hasExactSynonym "BI1821736" @default.
- NCIT_C200910 hasExactSynonym "Oncolytic VSV-GP BI 1821736" @default.
- NCIT_C200910 hasExactSynonym "Oncolytic VSV-GP-huCD80Fc BI 1821736" @default.
- NCIT_C200910 hasExactSynonym "VSV-GP BI 1821736" @default.
- NCIT_C200910 inSubset NCIT_C128784 @default.
- NCIT_C200910 inSubset NCIT_C157711 @default.
- NCIT_C200910 inSubset NCIT_C157712 @default.
- NCIT_C200910 inSubset NCIT_C176424 @default.
- NCIT_C200910 type Class @default.
- NCIT_C200910 isDefinedBy ncit.owl @default.
- NCIT_C200910 label "Oncolytic VSV-GP BI 1821736" @default.
- NCIT_C200910 subClassOf NCIT_C129821 @default.
- NCIT_C200910 subClassOf NCIT_C1908 @default.
- NCIT_C200910 subClassOf NCIT_C1909 @default.
- NCIT_C200910 subClassOf NCIT_C200910 @default.
- NCIT_C200910 subClassOf NCIT_C274 @default.
- NCIT_C200910 subClassOf NCIT_C307 @default.
- NCIT_C200910 subClassOf NCIT_C717 @default.