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- NCIT_C201068 IAO_0000115 "A monoclonal antibody targeting the co-inhibitory receptor lymphocyte-activation gene 3 protein (LAG-3; LAG3; CD223), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-LAG-3 monoclonal antibody GLS-012 targets and binds to LAG-3 expressed by tumor infiltrating lymphocytes (TILs) and blocks the interaction between LAG-3 and major histocompatibility complex class II (MHC II) molecules on the surface of antigen-presenting cells (APCs) and tumor cells. This prevents the negative regulation of T-cell activity that occurs via LAG-3-MHC II binding and enhances a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells, leading to a reduction in tumor growth. LAG-3, a member of the immunoglobulin superfamily (IgSF), negatively regulates both the proliferation and activation of T-cells. Its expression on TILs is associated with tumor-mediated immune suppression." @default.
- NCIT_C201068 NCIT_A7 NCIT_C104623 @default.
- NCIT_C201068 NCIT_NHC0 "C201068" @default.
- NCIT_C201068 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201068 NCIT_P108 "Anti-LAG-3 Monoclonal Antibody GLS-012" @default.
- NCIT_C201068 NCIT_P322 "GDC" @default.
- NCIT_C201068 NCIT_P399 "813444" @default.
- NCIT_C201068 NCIT_R124 NCIT_C17710 @default.
- NCIT_C201068 NCIT_R124 NCIT_C17828 @default.
- NCIT_C201068 NCIT_R124 NCIT_C18219 @default.
- NCIT_C201068 NCIT_R124 NCIT_C19986 @default.
- NCIT_C201068 NCIT_R124 NCIT_C40474 @default.
- NCIT_C201068 normalizedInformationContent "100" @default.
- NCIT_C201068 referenceCount "1" @default.
- NCIT_C201068 hasExactSynonym "Anti-LAG-3 Monoclonal Antibody GLS-012" @default.
- NCIT_C201068 hasExactSynonym "GLS 012" @default.
- NCIT_C201068 hasExactSynonym "GLS-012" @default.
- NCIT_C201068 hasExactSynonym "GLS012" @default.
- NCIT_C201068 inSubset NCIT_C128784 @default.
- NCIT_C201068 inSubset NCIT_C157711 @default.
- NCIT_C201068 inSubset NCIT_C157712 @default.
- NCIT_C201068 inSubset NCIT_C176424 @default.
- NCIT_C201068 type Class @default.
- NCIT_C201068 isDefinedBy ncit.owl @default.
- NCIT_C201068 label "Anti-LAG-3 Monoclonal Antibody GLS-012" @default.
- NCIT_C201068 subClassOf NCIT_C129821 @default.
- NCIT_C201068 subClassOf NCIT_C129822 @default.
- NCIT_C201068 subClassOf NCIT_C134305 @default.
- NCIT_C201068 subClassOf NCIT_C141144 @default.
- NCIT_C201068 subClassOf NCIT_C143250 @default.
- NCIT_C201068 subClassOf NCIT_C163758 @default.
- NCIT_C201068 subClassOf NCIT_C1908 @default.
- NCIT_C201068 subClassOf NCIT_C1909 @default.
- NCIT_C201068 subClassOf NCIT_C200483 @default.
- NCIT_C201068 subClassOf NCIT_C201068 @default.
- NCIT_C201068 subClassOf NCIT_C20401 @default.
- NCIT_C201068 subClassOf NCIT_C274 @default.
- NCIT_C201068 subClassOf NCIT_C307 @default.
- NCIT_C201068 subClassOf NCIT_C308 @default.