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- NCIT_C201072 IAO_0000115 "A trispecific T-cell engaging (TCE) antibody directed against two different epitopes of the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-DLL3/DLL3/CD3 trispecific antibody ZG006 binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the DLL3 antigen on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation." @default.
- NCIT_C201072 NCIT_A7 NCIT_C104256 @default.
- NCIT_C201072 NCIT_NHC0 "C201072" @default.
- NCIT_C201072 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201072 NCIT_P108 "Anti-DLL3/DLL3/CD3 Trispecific Antibody ZG006" @default.
- NCIT_C201072 NCIT_P322 "GDC" @default.
- NCIT_C201072 NCIT_P399 "813458" @default.
- NCIT_C201072 NCIT_R124 NCIT_C17710 @default.
- NCIT_C201072 NCIT_R124 NCIT_C17828 @default.
- NCIT_C201072 NCIT_R124 NCIT_C18219 @default.
- NCIT_C201072 NCIT_R124 NCIT_C19986 @default.
- NCIT_C201072 NCIT_R124 NCIT_C40474 @default.
- NCIT_C201072 normalizedInformationContent "100" @default.
- NCIT_C201072 referenceCount "1" @default.
- NCIT_C201072 hasExactSynonym "Anti-DLL3/DLL3/CD3 Trispecific Antibody ZG006" @default.
- NCIT_C201072 hasExactSynonym "DLL3 x DLL3 x CD3 Trispecific Antibody ZG006" @default.
- NCIT_C201072 hasExactSynonym "T-cell Engaging Antibody ZG006" @default.
- NCIT_C201072 hasExactSynonym "TCE Antibody ZG006" @default.
- NCIT_C201072 hasExactSynonym "ZG 006" @default.
- NCIT_C201072 hasExactSynonym "ZG-006" @default.
- NCIT_C201072 hasExactSynonym "ZG006" @default.
- NCIT_C201072 inSubset NCIT_C128784 @default.
- NCIT_C201072 inSubset NCIT_C157711 @default.
- NCIT_C201072 inSubset NCIT_C157712 @default.
- NCIT_C201072 inSubset NCIT_C176424 @default.
- NCIT_C201072 type Class @default.
- NCIT_C201072 isDefinedBy ncit.owl @default.
- NCIT_C201072 label "Anti-DLL3/DLL3/CD3 Trispecific Antibody ZG006" @default.
- NCIT_C201072 subClassOf NCIT_C112883 @default.
- NCIT_C201072 subClassOf NCIT_C129821 @default.
- NCIT_C201072 subClassOf NCIT_C129822 @default.
- NCIT_C201072 subClassOf NCIT_C163758 @default.
- NCIT_C201072 subClassOf NCIT_C1908 @default.
- NCIT_C201072 subClassOf NCIT_C1909 @default.
- NCIT_C201072 subClassOf NCIT_C200611 @default.
- NCIT_C201072 subClassOf NCIT_C200615 @default.
- NCIT_C201072 subClassOf NCIT_C201072 @default.
- NCIT_C201072 subClassOf NCIT_C20401 @default.
- NCIT_C201072 subClassOf NCIT_C274 @default.
- NCIT_C201072 subClassOf NCIT_C307 @default.
- NCIT_C201072 subClassOf NCIT_C308 @default.