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- NCIT_C201077 IAO_0000115 "A lyophilized form of recombinant human interferon (IFN) beta-1a (rhIFNb-1a), with potential protective activity. Upon dissolution of lyophilized rhIFNb-1a FP-1201 and intravenous administration, IFNb-1a upregulates the expression of and increases the levels of 5'-nucleotidase (CD73). This induces adenosine monophosphate (AMP) degradation and the production of adenosine. Adenosine acts to enhance endothelial barrier function via adenosine receptor activation and may prevent or reduce the increased vascular leakage that is due to the lack of adenosine. By increasing adenosine, rhIFNb-1a may protect the lining of blood vessels and thereby reduce inflammation. In addition, FP-1201 may prevent cytokine release syndrome (CRS) and immune effector cell associated-neurotoxicity syndrome (ICANS) toxicities in certain patients receiving CAR T-cell therapy. CD73 is abundantly expressed by normal endothelial cells." @default.
- NCIT_C201077 NCIT_NHC0 "C201077" @default.
- NCIT_C201077 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201077 NCIT_P108 "Lyophilized Human Recombinant Interferon-beta 1a FP-1201" @default.
- NCIT_C201077 NCIT_P322 "GDC" @default.
- NCIT_C201077 NCIT_P399 "813389" @default.
- NCIT_C201077 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C201077 NCIT_R125 NCIT_C21049 @default.
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- NCIT_C201077 NCIT_R146 NCIT_C21176 @default.
- NCIT_C201077 NCIT_R146 NCIT_C26548 @default.
- NCIT_C201077 NCIT_R146 NCIT_C37274 @default.
- NCIT_C201077 normalizedInformationContent "100" @default.
- NCIT_C201077 referenceCount "1" @default.
- NCIT_C201077 hasExactSynonym "FP 1201" @default.
- NCIT_C201077 hasExactSynonym "FP-1201" @default.
- NCIT_C201077 hasExactSynonym "FP-1201-lyo" @default.
- NCIT_C201077 hasExactSynonym "FP1201" @default.
- NCIT_C201077 hasExactSynonym "Lyophilized Human Recombinant IFN-b-1a FP-1201" @default.
- NCIT_C201077 hasExactSynonym "Lyophilized Human Recombinant IFN-beta-1a FP-1201" @default.
- NCIT_C201077 hasExactSynonym "Lyophilized Human Recombinant Interferon-beta 1a FP-1201" @default.
- NCIT_C201077 hasExactSynonym "Lyophilized rhIFNb-1a FP-1201" @default.
- NCIT_C201077 hasExactSynonym "Traumakine (TM)" @default.
- NCIT_C201077 inSubset NCIT_C128784 @default.
- NCIT_C201077 inSubset NCIT_C157711 @default.
- NCIT_C201077 inSubset NCIT_C157712 @default.
- NCIT_C201077 inSubset NCIT_C176424 @default.
- NCIT_C201077 type Class @default.
- NCIT_C201077 isDefinedBy ncit.owl @default.
- NCIT_C201077 label "Lyophilized Human Recombinant Interferon-beta 1a FP-1201" @default.
- NCIT_C201077 subClassOf NCIT_C1283 @default.
- NCIT_C201077 subClassOf NCIT_C1908 @default.
- NCIT_C201077 subClassOf NCIT_C1909 @default.
- NCIT_C201077 subClassOf NCIT_C201077 @default.
- NCIT_C201077 subClassOf NCIT_C307 @default.
- NCIT_C201077 subClassOf NCIT_C308 @default.
- NCIT_C201077 subClassOf NCIT_C495 @default.
- NCIT_C201077 subClassOf NCIT_C584 @default.