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- NCIT_C201084 IAO_0000115 "An inhalation powder formulation composed of a fixed combination of the furoate salt form of the glucocorticoid fluticasone, the bromide salt form of the muscarinic receptor antagonist umeclidinium, and the triphenylacetate salt form of the long-acting beta-2 adrenergic agonist vilanterol, with anti-inflammatory and bronchodilator activities. Upon oral inhalation of the fluticasone furoate/umeclidinium bromide/vilanterol trifenatate inhalation powder via an inhaler, fluticasone binds to intracellular glucocorticoid receptors (GRs), exhibiting inhibitory activities against multiple cell types and mediators associated with inflammation. Umeclidinium antagonizes M3 muscarinic receptors located on smooth muscle cells, thereby preventing smooth muscle contraction and resulting in bronchodilation. Vilanterol stimulates beta-2 adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells." @default.
- NCIT_C201084 NCIT_NHC0 "C201084" @default.
- NCIT_C201084 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201084 NCIT_P108 "Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate Inhalation Powder" @default.
- NCIT_C201084 normalizedInformationContent "100" @default.
- NCIT_C201084 referenceCount "1" @default.
- NCIT_C201084 hasExactSynonym "Fluticasone Furoate-Umeclidinium Bromide-Vilanterol Trifenatate Inhalation Powder" @default.
- NCIT_C201084 hasExactSynonym "Fluticasone Furoate-Umeclidinium Bromide-Vilanterol Trifenatate Inhalation" @default.
- NCIT_C201084 hasExactSynonym "Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate Inhalation Powder" @default.
- NCIT_C201084 hasExactSynonym "Fluticasone-Umeclidinium-Vilanterol Inhalation Powder" @default.
- NCIT_C201084 hasExactSynonym "Fluticasone/Umeclidinium/Vilanterol Inhalation Powder" @default.
- NCIT_C201084 hasExactSynonym "Trelegy Ellipta" @default.
- NCIT_C201084 type Class @default.
- NCIT_C201084 isDefinedBy ncit.owl @default.
- NCIT_C201084 label "Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate Inhalation Powder" @default.
- NCIT_C201084 subClassOf NCIT_C1908 @default.
- NCIT_C201084 subClassOf NCIT_C1909 @default.
- NCIT_C201084 subClassOf NCIT_C201084 @default.
- NCIT_C201084 subClassOf NCIT_C29712 @default.
- NCIT_C201084 subClassOf NCIT_C78273 @default.