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- NCIT_C201131 IAO_0000115 "An off-the-shelf (OTS) plasmid DNA cancer vaccine containing two DNA plasmids, one encoding for the two human cytomegalovirus (CMV) antigens immediate-early 1 (IE-1) and the matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) fused to the lysosome-associated membrane protein 1 (LAMP-1), and one plasmid encoding for the CMV glycoprotein B (gB) antigen which is also fused to LAMP-1, with potential immunomodulating and antineoplastic activities, Upon intramuscular (IM) administration and following electroporation, the DNA plasmid vaccine ITI-1001 is taken up by antigen presenting cells (APCs) and transported via LAMP-1 and the lysosome-mediated pathway. This results in enhanced major histocompatibility (MHC) class II antigen presentation of the three antigens to the immune system, thereby promoting CD4-positive T-cell responses as well as CD8-positive T-cell responses against tumor cells expressing the three viral antigens. IE1, pp65 and gB are expressed in certain tumor types. The incorporation of LAMP-1 routes the CMV antigens into the lysosomal compartment." @default.
- NCIT_C201131 NCIT_NHC0 "C201131" @default.
- NCIT_C201131 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C201131 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201131 NCIT_P107 "DNA Plasmid Vaccine ITI-1001" @default.
- NCIT_C201131 NCIT_P108 "DNA Plasmid Vaccine ITI-1001" @default.
- NCIT_C201131 NCIT_P322 "CTRP" @default.
- NCIT_C201131 NCIT_P322 "GDC" @default.
- NCIT_C201131 normalizedInformationContent "100" @default.
- NCIT_C201131 referenceCount "1" @default.
- NCIT_C201131 hasExactSynonym "CMV Antigens Vaccine ITI-1001" @default.
- NCIT_C201131 hasExactSynonym "DNA Plasmid Vaccine ITI-1001" @default.
- NCIT_C201131 hasExactSynonym "DNA Vaccine ITI-1001" @default.
- NCIT_C201131 hasExactSynonym "IE-1/pp65/gB-encoding pDNA Vaccine ITI-1001" @default.
- NCIT_C201131 hasExactSynonym "ITI 1001" @default.
- NCIT_C201131 hasExactSynonym "ITI-1001" @default.
- NCIT_C201131 hasExactSynonym "ITI1001" @default.
- NCIT_C201131 hasExactSynonym "pDNA Vaccine ITI-1001" @default.
- NCIT_C201131 inSubset NCIT_C116977 @default.
- NCIT_C201131 inSubset NCIT_C116978 @default.
- NCIT_C201131 inSubset NCIT_C128784 @default.
- NCIT_C201131 inSubset NCIT_C157711 @default.
- NCIT_C201131 inSubset NCIT_C157712 @default.
- NCIT_C201131 inSubset NCIT_C176424 @default.
- NCIT_C201131 type Class @default.
- NCIT_C201131 isDefinedBy ncit.owl @default.
- NCIT_C201131 label "DNA Plasmid Vaccine ITI-1001" @default.
- NCIT_C201131 subClassOf NCIT_C129820 @default.
- NCIT_C201131 subClassOf NCIT_C1663 @default.
- NCIT_C201131 subClassOf NCIT_C1908 @default.
- NCIT_C201131 subClassOf NCIT_C1909 @default.
- NCIT_C201131 subClassOf NCIT_C201131 @default.
- NCIT_C201131 subClassOf NCIT_C274 @default.
- NCIT_C201131 subClassOf NCIT_C307 @default.
- NCIT_C201131 subClassOf NCIT_C308 @default.
- NCIT_C201131 subClassOf NCIT_C39619 @default.
- NCIT_C201131 subClassOf NCIT_C923 @default.