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- NCIT_C201142 IAO_0000115 "A bispecific antibody directed against the human negative immunoregulatory checkpoint receptor programmed cell death protein 1 (PD-1; PD1; PDCD1; CD279) and human transforming growth factor beta (TGF-beta) receptor II (TGFbRII), with potential immune checkpoint modulating and antineoplastic activities. Upon administration, anti-PD-1/anti-TGFbRII bispecific antibody INCA33890 targets and binds to both PD-1 and TGFbRII and prevents the activation of PD-1 and TGF-beta-mediated signaling pathways in the tumor microenvironment (TME). The binding of INCA33890 to PD-1 prevents the activation of PD-1 by its ligands, programmed cell death-1 ligand 1 (PD-L1; CD274) and/or 2 (PD-L2; CD273). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic T-lymphocyte (CTL)-mediated tumor cell lysis, which may lead to a reduction in tumor growth. The binding of INCA33890 to TGFbRII prevents the binding of TGF-beta to TGFbRII, thereby preventing the activation of the TGF-beta-mediated signaling pathway. This abrogates TGF-beta-mediated immunosuppression in the TME, increases natural killer (NK) cell and CTL activities, and inhibits tumor cell proliferation in susceptible tumor cells. PD-1, an inhibitory receptor belonging to the immunoglobulin superfamily (IgSF), is expressed on activated T-lymphocytes; it functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands and plays an important role in tumor evasion from host immunity. TGF-beta, a pro-inflammatory mediator, is upregulated in certain types of cancers and is involved in cancer cell proliferation, tumor progression, migration and invasion, and the suppression of the immune response." @default.
- NCIT_C201142 NCIT_A7 NCIT_C20457 @default.
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- NCIT_C201142 NCIT_A7 NCIT_C94697 @default.
- NCIT_C201142 NCIT_NHC0 "C201142" @default.
- NCIT_C201142 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201142 NCIT_P107 "Anti-PD-1/Anti-TGFbRII Bispecific Antibody INCA33890" @default.
- NCIT_C201142 NCIT_P108 "Anti-PD-1/Anti-TGFbRII Bispecific Antibody INCA33890" @default.
- NCIT_C201142 NCIT_P322 "CTRP" @default.
- NCIT_C201142 NCIT_P322 "GDC" @default.
- NCIT_C201142 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C201142 normalizedInformationContent "100" @default.
- NCIT_C201142 referenceCount "1" @default.
- NCIT_C201142 hasExactSynonym "Anti-PD-1/Anti-TGFbRII Bispecific Antibody INCA33890" @default.
- NCIT_C201142 hasExactSynonym "Anti-PD-1/TGFbRII Bispecific Antibody INCA33890" @default.
- NCIT_C201142 hasExactSynonym "INCA 33890" @default.
- NCIT_C201142 hasExactSynonym "INCA-33890" @default.
- NCIT_C201142 hasExactSynonym "INCA33890" @default.
- NCIT_C201142 hasExactSynonym "PD-1 x TGFbR2 Bispecific Antibody INCA33890" @default.
- NCIT_C201142 hasExactSynonym "PD-1 x TGFbRII Bispecific Antibody INCA33890" @default.
- NCIT_C201142 inSubset NCIT_C116977 @default.
- NCIT_C201142 inSubset NCIT_C116978 @default.
- NCIT_C201142 inSubset NCIT_C128784 @default.
- NCIT_C201142 inSubset NCIT_C157711 @default.
- NCIT_C201142 inSubset NCIT_C157712 @default.
- NCIT_C201142 inSubset NCIT_C176424 @default.
- NCIT_C201142 type Class @default.
- NCIT_C201142 isDefinedBy ncit.owl @default.
- NCIT_C201142 label "Anti-PD-1/Anti-TGFbRII Bispecific Antibody INCA33890" @default.
- NCIT_C201142 subClassOf NCIT_C124946 @default.
- NCIT_C201142 subClassOf NCIT_C128037 @default.
- NCIT_C201142 subClassOf NCIT_C141144 @default.
- NCIT_C201142 subClassOf NCIT_C143250 @default.
- NCIT_C201142 subClassOf NCIT_C1454 @default.
- NCIT_C201142 subClassOf NCIT_C163758 @default.
- NCIT_C201142 subClassOf NCIT_C1908 @default.
- NCIT_C201142 subClassOf NCIT_C1909 @default.
- NCIT_C201142 subClassOf NCIT_C201142 @default.
- NCIT_C201142 subClassOf NCIT_C20401 @default.
- NCIT_C201142 subClassOf NCIT_C274 @default.
- NCIT_C201142 subClassOf NCIT_C28227 @default.
- NCIT_C201142 subClassOf NCIT_C307 @default.
- NCIT_C201142 subClassOf NCIT_C308 @default.