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- NCIT_C201145 IAO_0000115 "A bispecific gamma delta T-cell engager (TCE) antibody targeting both the tumor-associated antigen (TAA) epidermal growth factor receptor (EGFR; HER1; ErbB1) and Vdelta2-T cell receptor (TCR) chain of Vgamma9Vdelta2 T-cells, with potential immunostimulating and antineoplastic activities. Upon administration, anti-EGFR gamma delta T-cell engaging bispecific antibody SGN-EGFRd2 binds to both EGFR-expressing tumor cells and Vgamma9Vdelta2 T-cells. This activates and redirects the Vgamma9Vdelta2 T-cells to EGFR-expressing tumor cells, and the Vgamma9Vdelta2 T-cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, the Vgamma9Vdelta2 T-cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The Vdelta2 gamma delta T-cell subset is one of the two major gamma delta T-cell subsets that is almost exclusively paired with the Vgamma9 chain. EGFR, overexpressed by a variety of cancers, plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C201145 NCIT_A7 NCIT_C17068 @default.
- NCIT_C201145 NCIT_NHC0 "C201145" @default.
- NCIT_C201145 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201145 NCIT_P108 "Anti-EGFR Gamma Delta T-cell Engaging Bispecific Antibody SGN-EGFRd2" @default.
- NCIT_C201145 NCIT_P322 "GDC" @default.
- NCIT_C201145 NCIT_P399 "813528" @default.
- NCIT_C201145 NCIT_R124 NCIT_C17710 @default.
- NCIT_C201145 NCIT_R124 NCIT_C17828 @default.
- NCIT_C201145 NCIT_R124 NCIT_C18219 @default.
- NCIT_C201145 NCIT_R124 NCIT_C19986 @default.
- NCIT_C201145 NCIT_R124 NCIT_C40474 @default.
- NCIT_C201145 normalizedInformationContent "100" @default.
- NCIT_C201145 referenceCount "1" @default.
- NCIT_C201145 hasExactSynonym "Anti-EGFR Gamma Delta T-cell Engaging Bispecific Antibody LAVA-1223" @default.
- NCIT_C201145 hasExactSynonym "Anti-EGFR Gamma Delta T-cell Engaging Bispecific Antibody SGN-EGFRd2" @default.
- NCIT_C201145 hasExactSynonym "Anti-EGFR Gamma Delta TCE Bispecific Antibody SGN-EGFRd2" @default.
- NCIT_C201145 hasExactSynonym "EGFR-targeting Gammabody LAVA-1223" @default.
- NCIT_C201145 hasExactSynonym "LAVA 1223" @default.
- NCIT_C201145 hasExactSynonym "LAVA-1223" @default.
- NCIT_C201145 hasExactSynonym "LAVA1223" @default.
- NCIT_C201145 hasExactSynonym "SGN EGFRd2" @default.
- NCIT_C201145 hasExactSynonym "SGN-EGFRd2" @default.
- NCIT_C201145 hasExactSynonym "SGNEGFRd2" @default.
- NCIT_C201145 inSubset NCIT_C128784 @default.
- NCIT_C201145 inSubset NCIT_C157711 @default.
- NCIT_C201145 inSubset NCIT_C157712 @default.
- NCIT_C201145 inSubset NCIT_C176424 @default.
- NCIT_C201145 type Class @default.
- NCIT_C201145 isDefinedBy ncit.owl @default.
- NCIT_C201145 label "Anti-EGFR Gamma Delta T-cell Engaging Bispecific Antibody SGN-EGFRd2" @default.
- NCIT_C201145 subClassOf NCIT_C129821 @default.
- NCIT_C201145 subClassOf NCIT_C129822 @default.
- NCIT_C201145 subClassOf NCIT_C133878 @default.
- NCIT_C201145 subClassOf NCIT_C1454 @default.
- NCIT_C201145 subClassOf NCIT_C163758 @default.
- NCIT_C201145 subClassOf NCIT_C163952 @default.
- NCIT_C201145 subClassOf NCIT_C1908 @default.
- NCIT_C201145 subClassOf NCIT_C1909 @default.
- NCIT_C201145 subClassOf NCIT_C201145 @default.
- NCIT_C201145 subClassOf NCIT_C20401 @default.
- NCIT_C201145 subClassOf NCIT_C274 @default.
- NCIT_C201145 subClassOf NCIT_C28227 @default.
- NCIT_C201145 subClassOf NCIT_C307 @default.
- NCIT_C201145 subClassOf NCIT_C308 @default.