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- NCIT_C201189 IAO_0000115 "An immunoconjugate composed of the recombinant human monoclonal antibody hu5B1, which targets the carbohydrate antigen sialyl Lewis A (carbohydrate antigen 19-9; CA19-9), that is conjugated to trans-cyclooctene (TCO), with potential use in pretargeted radioimmunotherapy (PRIT). Upon intravenous administration of anti-CA19-9 antibody hu5B1/TCO immunoconjugate (hu5B1-TCO), the anti-CA19-9 antibody moiety targets and binds to CA19-9-expressing tumor cells and unbound hu5B1-TCO is readily cleared from the body. Imaging of CA19-9-expressing cells using positron emission tomography (PET) can occur upon administration of copper Cu 64-Tz-SarAr, a tetrazine-based radioligand that binds to the TCO moiety of bound hu5B1-TCO. CA19-9, overexpressed on a number of different tumor cell types, plays a key role in tumor cell survival and metastasis." @default.
- NCIT_C201189 NCIT_A7 NCIT_C327 @default.
- NCIT_C201189 NCIT_NHC0 "C201189" @default.
- NCIT_C201189 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201189 NCIT_P107 "Anti-CA19-9 Antibody hu5B1/TCO Immunoconjugate" @default.
- NCIT_C201189 NCIT_P108 "Anti-CA19-9 Antibody hu5B1/TCO Immunoconjugate" @default.
- NCIT_C201189 NCIT_P322 "CTRP" @default.
- NCIT_C201189 normalizedInformationContent "100" @default.
- NCIT_C201189 referenceCount "1" @default.
- NCIT_C201189 hasExactSynonym "Anti-CA19-9 Antibody hu5B1/TCO Immunoconjugate" @default.
- NCIT_C201189 hasExactSynonym "Trans-cyclooctene-hu5B1 Immunoconjugate" @default.
- NCIT_C201189 hasExactSynonym "hu5B1-TCO" @default.
- NCIT_C201189 inSubset NCIT_C116977 @default.
- NCIT_C201189 inSubset NCIT_C116978 @default.
- NCIT_C201189 inSubset NCIT_C128784 @default.
- NCIT_C201189 inSubset NCIT_C176424 @default.
- NCIT_C201189 type Class @default.
- NCIT_C201189 isDefinedBy ncit.owl @default.
- NCIT_C201189 label "Anti-CA19-9 Antibody hu5B1/TCO Immunoconjugate" @default.
- NCIT_C201189 subClassOf NCIT_C1512 @default.
- NCIT_C201189 subClassOf NCIT_C1908 @default.
- NCIT_C201189 subClassOf NCIT_C1909 @default.
- NCIT_C201189 subClassOf NCIT_C201189 @default.
- NCIT_C201189 subClassOf NCIT_C307 @default.
- NCIT_C201189 subClassOf NCIT_C308 @default.