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- NCIT_C201209 IAO_0000115 "An orally available small molecule pan-inhibitor of the PIM serine/threonine kinase family, with potential antineoplastic activity. Upon oral administration, pan-PIM kinase inhibitor GDC-0570 binds to and prevents the activation of the three PIM family kinases, PIM1, PIM2 and PIM3. This prevents the activation of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress PIMs. PIMs, constitutively active proto-oncogenic serine/threonine kinases upregulated in various types of cancers, play key roles in tumor cell proliferation and survival." @default.
- NCIT_C201209 NCIT_A7 NCIT_C104800 @default.
- NCIT_C201209 NCIT_A7 NCIT_C178145 @default.
- NCIT_C201209 NCIT_A7 NCIT_C18600 @default.
- NCIT_C201209 NCIT_NHC0 "C201209" @default.
- NCIT_C201209 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201209 NCIT_P107 "pan-PIM Kinase Inhibitor GDC-0570" @default.
- NCIT_C201209 NCIT_P108 "pan-PIM Kinase Inhibitor GDC-0570" @default.
- NCIT_C201209 NCIT_P322 "CTRP" @default.
- NCIT_C201209 NCIT_P322 "GDC" @default.
- NCIT_C201209 normalizedInformationContent "100" @default.
- NCIT_C201209 referenceCount "1" @default.
- NCIT_C201209 hasExactSynonym "GDC 0570" @default.
- NCIT_C201209 hasExactSynonym "GDC-0570" @default.
- NCIT_C201209 hasExactSynonym "GDC0570" @default.
- NCIT_C201209 hasExactSynonym "NB 004" @default.
- NCIT_C201209 hasExactSynonym "NB-004" @default.
- NCIT_C201209 hasExactSynonym "NB004" @default.
- NCIT_C201209 hasExactSynonym "pan-PIM Kinase Inhibitor GDC-0570" @default.
- NCIT_C201209 hasExactSynonym "pan-PIM Kinase Inhibitor NB004" @default.
- NCIT_C201209 inSubset NCIT_C116977 @default.
- NCIT_C201209 inSubset NCIT_C116978 @default.
- NCIT_C201209 inSubset NCIT_C128784 @default.
- NCIT_C201209 inSubset NCIT_C157711 @default.
- NCIT_C201209 inSubset NCIT_C157712 @default.
- NCIT_C201209 inSubset NCIT_C176424 @default.
- NCIT_C201209 type Class @default.
- NCIT_C201209 isDefinedBy ncit.owl @default.
- NCIT_C201209 label "pan-PIM Kinase Inhibitor GDC-0570" @default.
- NCIT_C201209 subClassOf NCIT_C129824 @default.
- NCIT_C201209 subClassOf NCIT_C129825 @default.
- NCIT_C201209 subClassOf NCIT_C1404 @default.
- NCIT_C201209 subClassOf NCIT_C1908 @default.
- NCIT_C201209 subClassOf NCIT_C1909 @default.
- NCIT_C201209 subClassOf NCIT_C201209 @default.
- NCIT_C201209 subClassOf NCIT_C2189 @default.
- NCIT_C201209 subClassOf NCIT_C274 @default.
- NCIT_C201209 subClassOf NCIT_C471 @default.
- NCIT_C201209 subClassOf NCIT_C61074 @default.