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- NCIT_C201235 IAO_0000115 "A conformationally stabilized alpha-helical polypeptide and direct inhibitor of the oncogenic driver beta-catenin, with potential immunomodulating and antineoplastic activities. Upon administration, beta-catenin inhibitor FOG-001 penetrates into the cell where it targets and binds to beta-catenin, thereby preventing the interaction of beta-catenin with the transcriptional factor T-cell factor (TCF). This disrupts beta-catenin-dependent oncogenic signaling and prevents the transcription of Wnt target genes that regulate the proliferation, migration, invasion, and the metastatic potential of tumor cells, as well as genes regulating the immunosuppression of the tumor microenvironment (TME). Dysregulation of the Wnt/beta-catenin signaling pathway is found in a variety of tumors and drives oncogenesis." @default.
- NCIT_C201235 NCIT_A7 NCIT_C17478 @default.
- NCIT_C201235 NCIT_NHC0 "C201235" @default.
- NCIT_C201235 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201235 NCIT_P107 "Beta-catenin Inhibitor FOG-001" @default.
- NCIT_C201235 NCIT_P108 "Beta-catenin Inhibitor FOG-001" @default.
- NCIT_C201235 NCIT_P322 "CTRP" @default.
- NCIT_C201235 NCIT_P322 "GDC" @default.
- NCIT_C201235 normalizedInformationContent "100" @default.
- NCIT_C201235 referenceCount "1" @default.
- NCIT_C201235 hasExactSynonym "Beta-catenin Antagonist FOG-001" @default.
- NCIT_C201235 hasExactSynonym "Beta-catenin Inhibitor FOG-001" @default.
- NCIT_C201235 hasExactSynonym "FOG 001" @default.
- NCIT_C201235 hasExactSynonym "FOG-001" @default.
- NCIT_C201235 hasExactSynonym "FOG001" @default.
- NCIT_C201235 hasExactSynonym "Helicon FOG-001" @default.
- NCIT_C201235 hasExactSynonym "TCF-blocking Beta-catenin Inhibitor FOG-001" @default.
- NCIT_C201235 inSubset NCIT_C116977 @default.
- NCIT_C201235 inSubset NCIT_C116978 @default.
- NCIT_C201235 inSubset NCIT_C157711 @default.
- NCIT_C201235 inSubset NCIT_C157712 @default.
- NCIT_C201235 inSubset NCIT_C176424 @default.
- NCIT_C201235 type Class @default.
- NCIT_C201235 isDefinedBy ncit.owl @default.
- NCIT_C201235 label "Beta-catenin Inhibitor FOG-001" @default.
- NCIT_C201235 subClassOf NCIT_C1908 @default.
- NCIT_C201235 subClassOf NCIT_C1909 @default.
- NCIT_C201235 subClassOf NCIT_C201235 @default.
- NCIT_C201235 subClassOf NCIT_C2189 @default.
- NCIT_C201235 subClassOf NCIT_C274 @default.