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- NCIT_C201236 IAO_0000115 "Fc-engineered bispecific monoclonal antibody targeting both immune checkpoint regulatory proteins human programmed death-ligand 1 (PD-L1; CD274) and 2 (PD-L2; CD273), with potential immune checkpoint inhibitory, immunostimulating and antineoplastic activities. Upon administration, anti-PD-L1/PD-L2 bispecific antibody IMGS-001 simultaneously targets and binds to PD-L1 and PD-L2 expressed on tumor cells, immunosuppressive stromal cells and endothelial cells. PD-L1 and PD-L2 binding by IMGS-001 prevents both PD-L1 and PD-L2 from binding to and activating their receptor programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This abrogates PD-1-mediated signaling in T-cells and PD-1-mediated T-cell inhibition. This activates cytotoxic T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which may lead to a reduction in tumor growth. In addition, IMGS-001 induces antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), thereby killing PD-L1 and PD-L2-expressing cells in the tumor microenvironment (TME), and further abrogating the immunosuppressive nature of the TME. PD-L1 and PD-L2 binding to PD-1 on activated T-cells inhibits the expansion and survival of CD8-positive T-cells, suppresses the immune system and results in immune evasion." @default.
- NCIT_C201236 NCIT_A7 NCIT_C45438 @default.
- NCIT_C201236 NCIT_A7 NCIT_C96024 @default.
- NCIT_C201236 NCIT_NHC0 "C201236" @default.
- NCIT_C201236 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C201236 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201236 NCIT_P107 "Anti-PD-L1/PD-L2 Bispecific Antibody IMGS-001" @default.
- NCIT_C201236 NCIT_P108 "Anti-PD-L1/PD-L2 Bispecific Antibody IMGS-001" @default.
- NCIT_C201236 NCIT_P322 "CTRP" @default.
- NCIT_C201236 NCIT_P322 "GDC" @default.
- NCIT_C201236 NCIT_R124 NCIT_C17710 @default.
- NCIT_C201236 NCIT_R124 NCIT_C17828 @default.
- NCIT_C201236 NCIT_R124 NCIT_C18219 @default.
- NCIT_C201236 NCIT_R124 NCIT_C19986 @default.
- NCIT_C201236 NCIT_R124 NCIT_C40474 @default.
- NCIT_C201236 normalizedInformationContent "100" @default.
- NCIT_C201236 referenceCount "1" @default.
- NCIT_C201236 hasExactSynonym "Anti-PD-L1/PD-L2 Antibody IMGS-001" @default.
- NCIT_C201236 hasExactSynonym "Anti-PD-L1/PD-L2 Bispecific Antibody IMGS-001" @default.
- NCIT_C201236 hasExactSynonym "Anti-PD-L1/anti-PD-L2 Bispecific Monoclonal Antibody IMGS-001" @default.
- NCIT_C201236 hasExactSynonym "IMGS 001" @default.
- NCIT_C201236 hasExactSynonym "IMGS-001" @default.
- NCIT_C201236 hasExactSynonym "IMGS001" @default.
- NCIT_C201236 inSubset NCIT_C116977 @default.
- NCIT_C201236 inSubset NCIT_C116978 @default.
- NCIT_C201236 inSubset NCIT_C128784 @default.
- NCIT_C201236 inSubset NCIT_C157711 @default.
- NCIT_C201236 inSubset NCIT_C157712 @default.
- NCIT_C201236 inSubset NCIT_C176424 @default.
- NCIT_C201236 type Class @default.
- NCIT_C201236 isDefinedBy ncit.owl @default.
- NCIT_C201236 label "Anti-PD-L1/PD-L2 Bispecific Antibody IMGS-001" @default.
- NCIT_C201236 subClassOf NCIT_C128057 @default.
- NCIT_C201236 subClassOf NCIT_C129821 @default.
- NCIT_C201236 subClassOf NCIT_C129822 @default.
- NCIT_C201236 subClassOf NCIT_C141144 @default.
- NCIT_C201236 subClassOf NCIT_C143250 @default.
- NCIT_C201236 subClassOf NCIT_C1454 @default.
- NCIT_C201236 subClassOf NCIT_C156893 @default.
- NCIT_C201236 subClassOf NCIT_C163758 @default.
- NCIT_C201236 subClassOf NCIT_C1908 @default.
- NCIT_C201236 subClassOf NCIT_C1909 @default.
- NCIT_C201236 subClassOf NCIT_C191689 @default.
- NCIT_C201236 subClassOf NCIT_C191691 @default.
- NCIT_C201236 subClassOf NCIT_C201236 @default.
- NCIT_C201236 subClassOf NCIT_C20401 @default.
- NCIT_C201236 subClassOf NCIT_C274 @default.
- NCIT_C201236 subClassOf NCIT_C307 @default.
- NCIT_C201236 subClassOf NCIT_C308 @default.