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- NCIT_C201243 IAO_0000115 "Acetylcholinesterase (614 aa, ~68 kDa) is encoded by the human ACHE gene. This protein plays a role in acetylcholine hydrolysis, neuronal apoptosis and the structure of the Cartwright (Yt) blood group antigen." @default.
- NCIT_C201243 NCIT_NHC0 "C201243" @default.
- NCIT_C201243 NCIT_P100 "100740" @default.
- NCIT_C201243 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C201243 NCIT_P106 "Enzyme" @default.
- NCIT_C201243 NCIT_P107 "Acetylcholinesterase" @default.
- NCIT_C201243 NCIT_P108 "Acetylcholinesterase" @default.
- NCIT_C201243 NCIT_P171 "10890884" @default.
- NCIT_C201243 NCIT_P171 "12554700" @default.
- NCIT_C201243 NCIT_P322 "CTRP" @default.
- NCIT_C201243 NCIT_P93 "P22303" @default.
- NCIT_C201243 NCIT_P98 "Acetylcholinesterase exists in multiple molecular forms which differ in their oligomeric assembly and mode of cell attachment to the cell surface. Tailed ACHE (ACHE-T; synaptic ACHE; ACHE-S), is the hydrophilic species, which can form monomers or dimers and can form disulfide-linked tetramers when associated with collagenous or lipid-containing anchoring proteins that attach them to the basal lamina or to cell membranes. ACHE-T is most frequently expressed in brain and muscle cells. Hydrophobic ACHE (ACHE-H; erythrocytic ACHE; ACHE-E) has a cleavable hydrophobic peptide with a C-terminal GPI-anchor site and is expressed as disulfide linked dimers in erythrocyte membranes. The readthrough ACHE (read-through ACHE; ACHE-R) is a rare transcript that may be monomeric and appears to be induced by acute stress responses in the brain. ACHE-R may counteract neuronal apoptosis and the neurodeterioration that ACHE-T can promote during abnormal cholinergic neurotransmission; therefore, ACHE-R may prevent the shift from transient, acute stress to progressive neurological disease.(UniProt, FASEB J. 2003;17:214-22 and PNAS. 2000;97:8647-8652.)" @default.
- NCIT_C201243 NCIT_P98 "Tailed ACHE is the UniProt canonical form of acetylcholinesterase." @default.
- NCIT_C201243 NCIT_R131 NCIT_C18611 @default.
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- NCIT_C201243 NCIT_R54 NCIT_C25804 @default.
- NCIT_C201243 NCIT_R54 NCIT_C25952 @default.
- NCIT_C201243 normalizedInformationContent "100" @default.
- NCIT_C201243 referenceCount "1" @default.
- NCIT_C201243 hasExactSynonym "ACHE" @default.
- NCIT_C201243 hasExactSynonym "AChE" @default.
- NCIT_C201243 hasExactSynonym "Acetylcholine Acetylhydrolase" @default.
- NCIT_C201243 hasExactSynonym "Acetylcholinesterase" @default.
- NCIT_C201243 hasExactSynonym "EC 3.1.1.7" @default.
- NCIT_C201243 inSubset NCIT_C116977 @default.
- NCIT_C201243 inSubset NCIT_C142799 @default.
- NCIT_C201243 inSubset NCIT_C142800 @default.
- NCIT_C201243 type Class @default.
- NCIT_C201243 isDefinedBy ncit.owl @default.
- NCIT_C201243 label "Acetylcholinesterase" @default.
- NCIT_C201243 subClassOf NCIT_C16554 @default.
- NCIT_C201243 subClassOf NCIT_C16561 @default.
- NCIT_C201243 subClassOf NCIT_C16701 @default.
- NCIT_C201243 subClassOf NCIT_C17021 @default.
- NCIT_C201243 subClassOf NCIT_C20027 @default.
- NCIT_C201243 subClassOf NCIT_C201243 @default.
- NCIT_C201243 subClassOf NCIT_C26548 @default.
- NCIT_C201243 equivalentClass B63634ca998d52b1c6a37745c738e477b @default.
- NCIT_C201243 equivalentClass Be99d7f7dedd5c2448d282953faa7003a @default.