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- NCIT_C201244 IAO_0000115 "A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against gremlin-1 (gremlin1; GREM1; Drm), with potential antineoplastic activity. Upon administration, anti-gremlin-1 monoclonal antibody TST003 specifically targets and binds to gremlin-1, thereby neutralizing gremlin-1 expressed on tumor cells and cancer associated fibroblasts (CAFs). This prevents binding to bone morphogenetic proteins (BMP), specifically to BMP2 and 4, and blocks the gremlin-1-mediated inhibition of BMP signaling pathways. This may lead to increased infiltration of CD8 T-cells into the tumor and may inhibit tumor cell growth and proliferation. Gremlin-1, a BMP antagonist and a member of the tumor growth factor (TGF)-beta superfamily, is overexpressed in a variety of cancer cell types. It is involved in cancer cell growth and proliferation, and promotes epithelial to mesenchymal transition (EMT). Overexpression of gremlin-1 is often associated with poor prognosis." @default.
- NCIT_C201244 NCIT_A7 NCIT_C152001 @default.
- NCIT_C201244 NCIT_NHC0 "C201244" @default.
- NCIT_C201244 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201244 NCIT_P107 "Anti-gremlin-1 Monoclonal Antibody TST003" @default.
- NCIT_C201244 NCIT_P108 "Anti-gremlin-1 Monoclonal Antibody TST003" @default.
- NCIT_C201244 NCIT_P322 "CTRP" @default.
- NCIT_C201244 NCIT_P322 "GDC" @default.
- NCIT_C201244 NCIT_R124 NCIT_C17710 @default.
- NCIT_C201244 NCIT_R124 NCIT_C17828 @default.
- NCIT_C201244 NCIT_R124 NCIT_C18219 @default.
- NCIT_C201244 NCIT_R124 NCIT_C19986 @default.
- NCIT_C201244 NCIT_R124 NCIT_C40474 @default.
- NCIT_C201244 normalizedInformationContent "100" @default.
- NCIT_C201244 referenceCount "1" @default.
- NCIT_C201244 hasExactSynonym "14E3" @default.
- NCIT_C201244 hasExactSynonym "Anti-GREM1 Monoclonal Antibody TST003" @default.
- NCIT_C201244 hasExactSynonym "Anti-gremlin-1 Monoclonal Antibody TST003" @default.
- NCIT_C201244 hasExactSynonym "TST 003" @default.
- NCIT_C201244 hasExactSynonym "TST-003" @default.
- NCIT_C201244 hasExactSynonym "TST003" @default.
- NCIT_C201244 inSubset NCIT_C116977 @default.
- NCIT_C201244 inSubset NCIT_C116978 @default.
- NCIT_C201244 inSubset NCIT_C128784 @default.
- NCIT_C201244 inSubset NCIT_C157711 @default.
- NCIT_C201244 inSubset NCIT_C157712 @default.
- NCIT_C201244 inSubset NCIT_C176424 @default.
- NCIT_C201244 type Class @default.
- NCIT_C201244 isDefinedBy ncit.owl @default.
- NCIT_C201244 label "Anti-gremlin-1 Monoclonal Antibody TST003" @default.
- NCIT_C201244 subClassOf NCIT_C129821 @default.
- NCIT_C201244 subClassOf NCIT_C129822 @default.
- NCIT_C201244 subClassOf NCIT_C1908 @default.
- NCIT_C201244 subClassOf NCIT_C1909 @default.
- NCIT_C201244 subClassOf NCIT_C201244 @default.
- NCIT_C201244 subClassOf NCIT_C20401 @default.
- NCIT_C201244 subClassOf NCIT_C274 @default.
- NCIT_C201244 subClassOf NCIT_C307 @default.
- NCIT_C201244 subClassOf NCIT_C308 @default.