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- NCIT_C201247 IAO_0000115 "An orally bioavailable, covalent and selective inhibitor of FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity. Upon oral administration, FLT3 inhibitor BMF-500 selectively targets and irreversibly binds to a reactive cysteine in the active site of FLT3. This inhibits the activity of FLT3 and prevents FLT3-mediated downstream signaling. This inhibits the proliferation of FLT3-expressing cancer cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias." @default.
- NCIT_C201247 NCIT_A7 NCIT_C26202 @default.
- NCIT_C201247 NCIT_NHC0 "C201247" @default.
- NCIT_C201247 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201247 NCIT_P107 "FLT3 Inhibitor BMF-500" @default.
- NCIT_C201247 NCIT_P108 "FLT3 Inhibitor BMF-500" @default.
- NCIT_C201247 NCIT_P322 "CTRP" @default.
- NCIT_C201247 NCIT_P322 "GDC" @default.
- NCIT_C201247 normalizedInformationContent "100" @default.
- NCIT_C201247 referenceCount "1" @default.
- NCIT_C201247 hasExactSynonym "BMF 500" @default.
- NCIT_C201247 hasExactSynonym "BMF-500" @default.
- NCIT_C201247 hasExactSynonym "BMF500" @default.
- NCIT_C201247 hasExactSynonym "FLT3 Inhibitor BMF-500" @default.
- NCIT_C201247 inSubset NCIT_C116977 @default.
- NCIT_C201247 inSubset NCIT_C116978 @default.
- NCIT_C201247 inSubset NCIT_C128784 @default.
- NCIT_C201247 inSubset NCIT_C157711 @default.
- NCIT_C201247 inSubset NCIT_C157712 @default.
- NCIT_C201247 inSubset NCIT_C176424 @default.
- NCIT_C201247 type Class @default.
- NCIT_C201247 isDefinedBy ncit.owl @default.
- NCIT_C201247 label "FLT3 Inhibitor BMF-500" @default.
- NCIT_C201247 subClassOf NCIT_C124800 @default.
- NCIT_C201247 subClassOf NCIT_C1404 @default.
- NCIT_C201247 subClassOf NCIT_C163758 @default.
- NCIT_C201247 subClassOf NCIT_C163790 @default.
- NCIT_C201247 subClassOf NCIT_C1908 @default.
- NCIT_C201247 subClassOf NCIT_C1909 @default.
- NCIT_C201247 subClassOf NCIT_C1967 @default.
- NCIT_C201247 subClassOf NCIT_C201247 @default.
- NCIT_C201247 subClassOf NCIT_C274 @default.
- NCIT_C201247 subClassOf NCIT_C471 @default.