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- NCIT_C201277 IAO_0000115 "Along with the immunoglobulin G4 subclass (IgG4), this IgG subtype makes up a minor part of circulating antibodies in healthy individuals. The core hinge sequence contains approximately four times the number of amino acids as the other subclasses; allotypes of IgG3 can have up to 62 hinge residues and up to four interchain disulfide bonds. The increased hinge size for IgG3 increases the separation between the Fc (constant fragment) tail and Fab (antigen binding fragment) arms of antibodies of this subclass. This enhances the relative flexibility of the molecule, which may modulate antigen-binding capacity and immune complex formation, and may increase the affinity for binding to both Fc receptors and complement component C1q." @default.
- NCIT_C201277 NCIT_NHC0 "C201277" @default.
- NCIT_C201277 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C201277 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C201277 NCIT_P108 "IgG3" @default.
- NCIT_C201277 NCIT_P171 "25368619" @default.
- NCIT_C201277 NCIT_R44 NCIT_C21176 @default.
- NCIT_C201277 NCIT_R44 NCIT_C26548 @default.
- NCIT_C201277 NCIT_R52 NCIT_C16295 @default.
- NCIT_C201277 NCIT_R52 NCIT_C16725 @default.
- NCIT_C201277 NCIT_R52 NCIT_C17021 @default.
- NCIT_C201277 NCIT_R52 NCIT_C20027 @default.
- NCIT_C201277 NCIT_R52 NCIT_C26548 @default.
- NCIT_C201277 NCIT_R53 NCIT_C17710 @default.
- NCIT_C201277 NCIT_R53 NCIT_C17828 @default.
- NCIT_C201277 NCIT_R53 NCIT_C17930 @default.
- NCIT_C201277 NCIT_R53 NCIT_C17937 @default.
- NCIT_C201277 NCIT_R53 NCIT_C18219 @default.
- NCIT_C201277 NCIT_R53 NCIT_C18839 @default.
- NCIT_C201277 NCIT_R53 NCIT_C19986 @default.
- NCIT_C201277 NCIT_R53 NCIT_C21124 @default.
- NCIT_C201277 NCIT_R53 NCIT_C40474 @default.
- NCIT_C201277 NCIT_R54 NCIT_C16612 @default.
- NCIT_C201277 NCIT_R54 NCIT_C25790 @default.
- NCIT_C201277 normalizedInformationContent "100" @default.
- NCIT_C201277 referenceCount "1" @default.
- NCIT_C201277 hasExactSynonym "IgG3" @default.
- NCIT_C201277 hasExactSynonym "Immunoglobulin G Subclass 3" @default.
- NCIT_C201277 hasExactSynonym "Immunoglobulin G3" @default.
- NCIT_C201277 type Class @default.
- NCIT_C201277 isDefinedBy ncit.owl @default.
- NCIT_C201277 label "IgG3" @default.
- NCIT_C201277 subClassOf NCIT_C16295 @default.
- NCIT_C201277 subClassOf NCIT_C16725 @default.
- NCIT_C201277 subClassOf NCIT_C17021 @default.
- NCIT_C201277 subClassOf NCIT_C20027 @default.
- NCIT_C201277 subClassOf NCIT_C201277 @default.
- NCIT_C201277 subClassOf NCIT_C26548 @default.
- NCIT_C201277 subClassOf NCIT_C568 @default.
- NCIT_C201277 subClassOf NCIT_C572 @default.