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- NCIT_C201280 IAO_0000115 "A radioconjugate composed of PNT6555, a fibroblast activation protein (FAP)-targeting moiety linked to the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), radiolabeled with gallium Ga 68 (68Ga), with potential use as a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) and FAP-expressing tumor cells during positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-PNT6555, the FAP-targeting moiety targets and binds to FAP-expressing CAFs and tumor cells. Upon binding, FAP-expressing CAFs and tumor cells can be detected during PET/CT imaging. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME) and certain tumor cells." @default.
- NCIT_C201280 NCIT_A7 NCIT_C17799 @default.
- NCIT_C201280 NCIT_NHC0 "C201280" @default.
- NCIT_C201280 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201280 NCIT_P107 "Gallium Ga 68-PNT6555" @default.
- NCIT_C201280 NCIT_P108 "Gallium Ga 68-PNT6555" @default.
- NCIT_C201280 NCIT_P322 "CTRP" @default.
- NCIT_C201280 normalizedInformationContent "100" @default.
- NCIT_C201280 referenceCount "1" @default.
- NCIT_C201280 hasExactSynonym "68Ga-PNT6555" @default.
- NCIT_C201280 hasExactSynonym "Gallium Ga 68-PNT6555" @default.
- NCIT_C201280 hasExactSynonym "[Ga-68]-PNT6555" @default.
- NCIT_C201280 inSubset NCIT_C116977 @default.
- NCIT_C201280 inSubset NCIT_C116978 @default.
- NCIT_C201280 inSubset NCIT_C176424 @default.
- NCIT_C201280 type Class @default.
- NCIT_C201280 isDefinedBy ncit.owl @default.
- NCIT_C201280 label "Gallium Ga 68-PNT6555" @default.
- NCIT_C201280 subClassOf NCIT_C1446 @default.
- NCIT_C201280 subClassOf NCIT_C1511 @default.
- NCIT_C201280 subClassOf NCIT_C1512 @default.
- NCIT_C201280 subClassOf NCIT_C1908 @default.
- NCIT_C201280 subClassOf NCIT_C1909 @default.
- NCIT_C201280 subClassOf NCIT_C201280 @default.
- NCIT_C201280 subClassOf NCIT_C2124 @default.
- NCIT_C201280 subClassOf NCIT_C307 @default.
- NCIT_C201280 subClassOf NCIT_C308 @default.