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- NCIT_C201281 IAO_0000115 "A radioconjugate composed of PNT6555, a fibroblast activation protein (FAP)-targeting moiety linked to the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), radiolabeled with the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity. Upon administration of lutetium Lu 177-PNT6555, the FAP-targeting moiety targets and binds to FAP-expressing cancer-associated fibroblasts (CAFs) and FAP-expressing tumor cells. Upon binding, FAP-expressing CAFs and tumor cells are destroyed by 177Lu through the specific delivery of beta particle radiation. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME) and certain tumor cells." @default.
- NCIT_C201281 NCIT_A7 NCIT_C17799 @default.
- NCIT_C201281 NCIT_NHC0 "C201281" @default.
- NCIT_C201281 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C201281 NCIT_P107 "Lutetium Lu 177-PNT6555" @default.
- NCIT_C201281 NCIT_P108 "Lutetium Lu 177-PNT6555" @default.
- NCIT_C201281 NCIT_P322 "CTRP" @default.
- NCIT_C201281 NCIT_P322 "GDC" @default.
- NCIT_C201281 normalizedInformationContent "100" @default.
- NCIT_C201281 referenceCount "1" @default.
- NCIT_C201281 hasExactSynonym "177Lu-PNT6555" @default.
- NCIT_C201281 hasExactSynonym "Lutetium Lu 177-PNT6555" @default.
- NCIT_C201281 hasExactSynonym "[Lu-177]-PNT6555" @default.
- NCIT_C201281 inSubset NCIT_C116977 @default.
- NCIT_C201281 inSubset NCIT_C116978 @default.
- NCIT_C201281 inSubset NCIT_C128784 @default.
- NCIT_C201281 inSubset NCIT_C157711 @default.
- NCIT_C201281 inSubset NCIT_C157712 @default.
- NCIT_C201281 inSubset NCIT_C176424 @default.
- NCIT_C201281 type Class @default.
- NCIT_C201281 isDefinedBy ncit.owl @default.
- NCIT_C201281 label "Lutetium Lu 177-PNT6555" @default.
- NCIT_C201281 subClassOf NCIT_C129819 @default.
- NCIT_C201281 subClassOf NCIT_C1446 @default.
- NCIT_C201281 subClassOf NCIT_C1511 @default.
- NCIT_C201281 subClassOf NCIT_C1512 @default.
- NCIT_C201281 subClassOf NCIT_C1908 @default.
- NCIT_C201281 subClassOf NCIT_C1909 @default.
- NCIT_C201281 subClassOf NCIT_C201281 @default.
- NCIT_C201281 subClassOf NCIT_C2124 @default.
- NCIT_C201281 subClassOf NCIT_C274 @default.
- NCIT_C201281 subClassOf NCIT_C307 @default.
- NCIT_C201281 subClassOf NCIT_C308 @default.